Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy  

作　　者：Peng Zhao Tian Sun Cheng Lyu Kaini Liang Yanan Du 

机构地区：[1]Department of Biomedical Engineering,School of Medicine,Tsinghua‑Peking Center for Life Sciences,Tsinghua University,Beijing 100084,China

出　　处：《Cell Regeneration》2023年第1期91-106,共16页细胞再生（英文）

基　　金：financially supported by the National Natural Science Foundation of China(82125018).

摘　　要：Investigation into the role of cells with respect to extracellular matrix(ECM)remodeling is still in its infancy.Particularly,ECM degradation is an indispensable process during the recovery from fibrosis.Cells with ECM degradation ability due to the secretion of various matrix metalloproteinases(MMPs)have emerged as novel contributors to the treatment of fibrotic diseases.In this review,we focus on the ECM degradation ability of cells associated with the repertoire of MMPs that facilitate the attenuation of fibrosis through the inhibition of ECM deposition.Besides,innovative approaches to engineering and characterizing cells with degradation ability,as well as elucidating the mechanism of the ECM degradation,are also illustrated.Studies conducted to date on the use of cell-based degradation for therapeutic purposes to combat fibrosis are summarized.Finally,we discuss the therapeutic potential of cells with high degradation ability,hoping to bridge the gap between benchside research and bedside applications in treating fibrotic diseases.

关 键 词：FIBROSIS Extracellular matrix DEGRADATION Matrix metalloproteinases 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]