Cytotoxic phenazine and antiallergic phenoxazine alkaloids from an arctic Nocardiopsis dassonvillei SCSIO 502F  

作　　者：Yue Song Qi-Yang Li Meng-Jing Cong Xiao-Yan Pang Bo Chen Yong-Hong Liu Li Liao Jun-Feng Wang 

机构地区：[1]CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine,Materia Medica/Innovation Academy of South China Sea Ecology and Environmental Engineering,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China [2]Key Laboratory for Polar Science,MNR,Polar Research Institute of China,Shanghai 200136,China [3]Department of Pharmacology and Therapeutics,McGill University,Montreal H3A 0G4,Canada [4]University of Chinese Academy of Sciences,19 Yuquan Road,Beijing 100049,China [5]Sanya Institute of Marine Ecology and Engineering,Sanya 572000,China [6]School of Oceanography,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Natural Products and Bioprospecting》2023年第1期287-293,共7页应用天然产物（英文）

基　　金：the Guangdong Basic and Applied Basic Research Foundation(2021A1515011523,2021B1515120046,2022B1515120075);National Key Research and Development Program of China(2022YFC2807501);National Natural Science Foundation of China(grant no.41976224);Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City(2021JJLH0097,2021CXLH0013);Hainan Provincial Natural Science Foundation of China(823CXTD393)。

摘　　要：Microbes well-adapted to the Arctic Ocean are promising for producing novel compounds,due to their fancy strategies for adaptation and being under-investigated.Two new phenazine alkaloids(1 and 2)and one new phenoxa-zine(3)were isolated from Nocardiopsis dassonvillei 502F,a strain originally isolated from Arctic deep-sea sediments.AntiSMASH analysis of the genome of Nocardiopsis dassonvillei 502F revealed the presence of 16 putative biosynthetic gene clusters(BGCs),including a phenazine BGC.Most of the isolated compounds were evaluated for their antibacterial,antiallergic,and cytotoxic activities.Among them,compounds 4 and 5 exhibited potent in vitro cytotoxic activities against osteosarcoma cell line 143B with IC_(50) values 0.16 and 20.0μM,respectively.Besides,the results of antiallergic activities of compounds 6-8 exhibited inhibitory activities with IC_(50) values of 10.88±3.05,38.88±3.29,and 2.44±0.17μg/mL,respectively(IC_(50)91.6μM for the positive control loratadine).

关 键 词：Nocardiopsis dassonvillei Arctic Ocean PHENAZINE PHENOXAZINE CYTOTOXIC ANTIALLERGIC 

分 类 号：O62[理学—有机化学]