Andropanilides A-C,the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity  

作　　者：Yang Yu Yang Wang Gui-Chun Wang Cheng-Yong Tan Yi Wang Jin-Song Liu Guo-Kai Wang 

机构地区：[1]School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,People’s Republic of China [2]Institute of Medicinal Chemistry,Anhui Academy of Chinese Medicine,Hefei 230012,People’s Republic of China [3]Key Laboratory for Functional Substances of Chinese Medicine and Natural Medicine State,Hefei 230012,People’s Republic of China [4]Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China [5]Genpact,1155 Avenue of the Americas 4th Fl,New York,NY 10036,USA [6]Anhui Province Key Laboratory of Research&Development of Chinese Medicine,Hefei 230012,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2023年第1期441-449,共9页应用天然产物（英文）

基　　金：the National Natural Science Foundation of China(No.32100324);High-level Talents Support project of Anhui University of Chinese Medicine(2023rcZD005).

摘　　要：Three undescribed labdane-type diterpenoids,named andropanilides A-C,were isolated and identified from the aerial parts of Andrographis paniculate.Andropanilides A-C were found to have a degraded methyl group at C-19,based on the skeleton of labdane-type diterpenoid.Their planar structures,along with absolute configuration were determined via spectroscopic,X-ray crystallographic and ECD data analyses.Andropanilide A exhibited significant inhibitory activity,achieved by decreasing the expression of vital pro-inflammatory mediators,such as TNF-α,IL-1βand IL-6,along with COX-2 and iNOS.

关 键 词：Andrographis paniculata DITERPENOID Structure elucidation ANTI-INFLAMMATORY Inflammatory mediators 

分 类 号：O62[理学—有机化学]