PMS2、MTA1及VCAM⁃1在结肠癌病情与预后评估中的作用  

The role of PMS2,MTA1 and VCAM⁃1 in the evaluation of colon cancer and prognosis

作　　者：席乐峰 张德臣 王利勤 李凤营 赵智 XI Lefeng;ZHANG Dechen;WANG Liqin;LI Fengying;ZHAO Zhi(Department of Pathology,Zhengzhou Yihe Hospital,Zhengzhou,Henan,China,450000)

机构地区：[1]郑州颐和医院病理科,河南郑州450000

出　　处：《分子诊断与治疗杂志》2024年第8期1403-1406,1411,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(LHGJ20210801)。

摘　　要：目的 探讨减数分裂后分离蛋白2(PMS2)、肿瘤转移相关基因1(MTA1)及血管细胞黏附分子-1(VCAM-1)在结肠癌病情与预后评估中的作用。方法 选取2019年1月至2021年3月郑州颐和医院收治的结肠癌患者81例为研究对象,患者均接受手术治疗。选取81例结肠癌患者的结肠癌组织(癌组织组)和距肿瘤边缘4 cm的癌旁组织(癌旁组织组),比较两组PMS2、MTA1、VCAM-1的表达情况;分析PMS2、MTA1、VCAM-1在不同病理特征中的表达水平;分析影响结肠癌患者生存的COX单因素与多因素;比较不同PMS2、MTA1、VCAM-1表达者的预后生存率。结果 癌组织组中PMS2、MTA1、VCAM-1表达阳性率显著高于癌旁组织组,差异有统计学意义(P<0.05)。TNM分期Ⅲ~Ⅳ期患者PMS2(+)、MTA1(+)、VCAM-1(+)均高于Ⅰ~Ⅱ期患者、有淋巴结转移患者PMS2(+)、MTA1(+)、VCAM-1(+)均高于无淋巴结转移患者、低分化程度患者PMS2(+)、MTA1(+)、VCAM-1(+)均高于高、中分化程度患者,差异有统计学意义(P<0.05),但不同肿瘤大小患者PMS2(+)、MTA1(+)、VCAM-1(+)比较,差异无统计学意义(P>0.05)。COX单因素分析显示:组织分化(G3)、TNM分期(Ⅲ~Ⅳ期)、远处(有)、PMS2(+)、MTA1(+)、VCAM-1(+)是影响结肠癌患者死亡的不良预后因素(P<0.05);COX多因素分析显示:组织分化(G3)、TNM分期(Ⅲ~Ⅳ期)、远处转移(有)、PMS2(+)、MTA1(+)、VCAM-1(+)是影响结肠癌患者死亡的独立预后危险因素(P<0.05)。PMS2阳性组生存率低于阴性组,差异有统计学意义(χ^(2)=6.688,P<0.05);MTA1阴性组生存率低于阳性组,差异有统计学意义(χ^(2)=7.161,P<0.05);VCAM-1阴性组生存率低于阳性组,差异有统计学意义(χ^(2)=9.527,P<0.05)。结论 PMS2、MTA1、VCAM-1在结肠癌组织中呈高表达状态,通过检测三指标的表达情况,可更准确判断患者病情严重程度及预后风险。Objective To investigate the role of postmeiotic protein 2(PMS2),tumor metastasis⁃associated gene 1(MTA1)and vascular cell adhesion molecule⁃1(VCAM⁃1)in the evaluation of colon cancer and prognosis.Methods A total of 81 patients with colon cancer who were admitted to Zhengzhou Yihe Hospital from January 2019 to March 2021 were selected as the study subjects.All patients underwent surgical treatment.The expression of PMS2,MTA1 and VCAM⁃1 in colon cancer tissues and adjacent tissues of these patients was compared.The expression levels of PMS2,MTA1 and VCAM⁃1 in different pathological features were analyzed.The COX univariate and multivariate factors affecting the survival of patients with colon cancer were examined.The prognostic survival rates of patients with different PMS2,MTA1 and VCAM⁃1 expression were compared.Results The positive expression rates of PMS2,MTA1 and VCAM⁃1 in colon cancer tissues were significantly higher than those in adjacent tissues,and the differences were statistically significant(P<0.05).PMS2(+),MTA1(+)and VCAM⁃1(+)in TNM stageⅢ~Ⅳwere higher than those in TNM stageⅠ~Ⅱ,PMS2(+),MTA1(+)and VCAM⁃1(+)in lymph node metastasis were higher than those in no lymph node metastasis,PMS2(+),MTA1(+)and VCAM⁃1(+)in low differentiation were higher than those in high and medium differentiation,and the differences were statistically significant(P<0.05).However,there was no significant difference in PMS2(+),MTA1(+)and VCAM⁃1(+)between different tumor sizes(P>0.05).COX univariate analysis showed that tissue differentiation(G3),TNM stage(Ⅲ~Ⅳ),distant(yes),PMS2(+),MTA1(+),VCAM⁃1(+)were the poor prognostic factors affecting the death of colon cancer patients(P<0.05).COX multivariate analysis showed that tissue differentiation(G3),TNM stage(Ⅲ~Ⅳ),distant metastasis(yes),PMS2(+),MTA1(+),VCAM⁃1(+)were independent prognostic risk factors for death in patients with colon cancer(P<0.05).The survival rate of the PMS2 positive group was lower than that of the negative group,the

关 键 词：PMS2 MTA1 VCAM⁃1 结肠癌 

分 类 号：R735.35[医药卫生—肿瘤]