化疗联合免疫治疗局部晚期食管癌疗效及对Sil⁃2R、IFN⁃γ、TSGF水平的影响  

Effect of neoadjuvant chemotherapy combined with immunotherapy on locally advanced esophageal cancer and its influence on Sil⁃2R,IFN⁃γand TSGF levels

作　　者：魏丹丹 方金满 王明喜[2] 王伟 汤振 WEI Dandan;FANG Jinman;WANG Mingxi;WANG Wei;TANG Zhen(Gastrointestinal Cancer Center,Hefei Cancer Hospital,Chinese Academy of Sciences,Hefei,Anhui,China,230031;Department of Oncology,The First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui,China,233000)

机构地区：[1]中国科学院合肥肿瘤医院胃肠肿瘤中心,安徽合肥230031 [2]蚌埠医学院第一附属医院肿瘤内科,安徽蚌埠233000

出　　处：《分子诊断与治疗杂志》2024年第8期1524-1528,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省科技重大专项(202103a07020012);安徽省重点研究与开发计划(2022e07020054);2022年合肥研究院院长基金项目(YZJJ2023QN49)。

摘　　要：目的研究化疗联合免疫治疗局部晚期食管癌(LAEC)疗效及对可溶性白细胞介素⁃2受体(Sil⁃2R)、γ⁃干扰素(IFN⁃γ)及恶性肿瘤特异生长因子(TSGF)水平的影响。方法选择2021年3月至2023年7月于中国科学院合肥肿瘤医院治疗的LAEC患者106例,依据随机数字表法将106例患者分为试验组(n=53)、对照组(n=53)。对照组行标准化疗,试验组行化疗联合免疫治疗。观察两组临床疗效、不良反应,比较两组治疗前后血清程序性死亡配体1(PD⁃L1)、程序性死亡受体1(PD⁃1)、Sil⁃2R、IFN⁃γ、TSGF水平。结果试验组客观缓解率(ORR)、疾病控制率(DCR)均高于对照组,差异有统计学意义(P<0.05)。两组治疗期间各不良反应分级比较差异无统计学意义(P>0.05)。治疗后,试验组血清PD⁃L1、PD⁃1及Sil⁃2R、TSGF水平均低于对照组,血清IFN⁃γ水平高于对照组,差异有统计学意义(P<0.05)。结论化疗联合免疫治疗可有效降低LAEC患者免疫检查点活性,增强机体免疫,可促进产生IFN⁃γ,抑制Sil⁃2R、TSGF生成,疗效较好,且不增加不良反应,具有一定的临床应用价值。Objective To investigate the efficacy of neoadjuvant chemotherapy combined with im⁃munotherapy in the treatment of locally advanced esophageal cancer(LAEC)and its effects on the levels of soluble interleukin⁃2 receptor(Sil⁃2R),gamma⁃interferon(IFN⁃γ)and malignant tumor⁃specific growth factor(TSGF).Methods A total of 106 LAEC patients treated at Hefei Cancer Hospital,Chinese Academy of Sci⁃ences,from March 2021 to July 2023 were selected.They were divided into an experimental group(n=53)and a control group(n=53)using a random number table method.The control group received neoadjuvant chemo⁃therapy,while the experimental group received neoadjuvant chemotherapy combined with immunotherapy.The clinical efficacy,adverse reactions,serum levels of programmed death ligand 1(PD⁃L1),programmed death receptor 1(PD⁃1),Sil⁃2R,IFN⁃γand TSGF were compared before and after treatment in both groups.Results The objective response rate(ORR)and disease control rate(DCR)in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the grade of adverse reactions between the two groups(P>0.05).After treatment,se⁃rum levels of PD⁃L1,PD⁃1,Sil⁃2R and TSGF in the experimental groups were lower than those in the control group,and serum levels of IFN⁃γwere higher than those in the control group,and the differences were statisti⁃cally significant(P<0.05).Conclusion Neoadjuvant chemotherapy combined with immunotherapy can effec⁃tively reduce immune checkpoint activity in LAEC patients,enhance the body's immunity,promote the produc⁃tion of IFN⁃γ,and inhibit the production of Sil⁃2R and TSGF.It has shown good efficacy without increasing ad⁃verse reactions,making it a valuable option for clinical application.

关 键 词：化疗 免疫治疗 局部晚期食管癌 Sil⁃2R IFN⁃γ TSGF 

分 类 号：R735.1[医药卫生—肿瘤]