HSD17B6的主要功能及其在内分泌代谢和肿瘤中的作用  

The main function of HSD17B6 and its role in endocrine metabolism and tumors

作　　者：王鑫[1] 冯寒笑 郝雯琪 张扬 魏凤香 WANG Xin;FENG Hanxiao;HAO Wenqi;ZHANG Yang;WEI Fengxiang(School of Clinical Medicine,Jiamusi University,Jiamusi,Heilongjiang,China,154007;School of Pub-lic Health,Sun Yat-sen University(Shenzhen),Shenzhen,Guangdong,China,518172;Otolaryngology Department,The First Affiliated Hospital of Jiamusi University,Jiamusi,Heilongjiang,China,154007;Central Laboratory,Longgang District Maternity&Child Healthcare Hospital of Shenzhen City,Shenzhen,Guangdong,China,518172;Longgang Maternal and Child Clinical College,Medical College Of Shantou University,Shenzhen,Guangdong,China,518172)

机构地区：[1]佳木斯大学临床医学院,黑龙江佳木斯154007 [2]中山大学公共卫生学院(深圳),广东深圳518172 [3]佳木斯大学附属第一医院耳鼻喉科,黑龙江佳木斯154007 [4]深圳市龙岗区妇幼保健院中心实验室,广东深圳518172 [5]汕头大学医学院龙岗妇幼临床学院,广东深圳518172

出　　处：《分子诊断与治疗杂志》2024年第8期1604-1608,共5页Journal of Molecular Diagnostics and Therapy

基　　金：深圳市科技计划项目(JCYJ20190808102405474)。

摘　　要：羟基类固醇脱氢酶是醛酮还原酶和短链脱氢酶⁃还原酶超家族的成员,对于类固醇激素在体内发挥正常功能起着至关重要的作用。HSD17B6是羟基类固醇脱氢酶中的一种,在体内主要参与雄激素的代谢和生物合成,产生雌激素受体β的高亲和力配体,进而可能影响体内糖脂代谢,造成内分泌及生殖系统的紊乱与疾病的发生。HSD17B6表达异常也与机体免疫功能有关,可参与肿瘤的发生与发展,作为潜在生物标志物用于肿瘤的诊断与评估,为药物或靶向治疗提供参考信息。尽管其对疾病影响的精细机制尚不明确,但HSD17B的功能丧失可能对机体造成不同程度的损伤。本文就HSD17B6在代谢病和肿瘤方面的作用进行综述。Hydroxysteroid dehydrogenase is a member of the aldokeone reductase and short chain dehydrogenase⁃reductase superfamily,which plays a crucial role in the normal function of steroid hormones in the body.HSD17B6 is one of the hydroxy steroid dehydrogenases,mainly involved in the metabolism and bio⁃synthesis of androgens in vivo.It produces the high affinity ligand of estrogen receptorβ,which may affect the metabolism of glucose and lipids in the body,leading to endocrine and reproductive system disorders and dis⁃eases.Abnormal expression of HSD17B6 is also related to the immune function of the body and can be involved in the occurrence and development of tumors.As a potential biomarker,HSD17B6 can be used for the diagnosis and evaluation of tumors,providing reference information for drugs or targeted therapies.Although the precise mechanism of its effect on disease remains unclear,the loss of function of HSD17B may cause varying degrees of damage to the body.This article reviews the role of HSD17B6 in metabolic diseases and tumors.

关 键 词：HSD17B6 雄激素 雌激素受体Β 糖脂代谢 代谢性疾病 肿瘤 

分 类 号：R363[医药卫生—病理学]