《关于慢性抽动障碍治疗失败定义的专家共识》解读  

Interpretation of expert clinicians′consensus-based definition for treatment failure in chronic tic disorders

作　　者：向雨欣 孙丹[1] 刘智胜[1] Xiang Yuxin;Sun Dan;Liu Zhisheng(Department of Neurology,Wuhan Children′s Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430016,China)

机构地区：[1]华中科技大学同济医学院附属武汉儿童医院神经内科,武汉430016

出　　处：《中华实用儿科临床杂志》2024年第9期650-654,共5页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家重点研发计划(2016YFC1306202);湖北省科技计划项目(2022DCC020)。

摘　　要：正确判断慢性抽动障碍治疗失败能防止持续使用不必要的治疗方法,有利于适时升级为试验性甚至侵入性治疗,但目前仍缺乏关于慢性抽动障碍治疗失败的标准定义。由加拿大卡尔加里大学Davide Martino教授牵头,通过网络平台开展了多轮德尔菲调查法,制定了《关于慢性抽动障碍治疗失败定义的专家共识》。该共识基于行为干预和药物治疗,从治疗无效、依从性、耐受性和共患病影响4个方面形成抽动障碍治疗失败,并且进一步确定了行为干预整体治疗失败以及药物治疗整体治疗失败的定义。现就该共识的制订流程及关键内容进行解读,并补充探讨近年来关注的难治性抽动障碍定义,以帮助临床医师提高对慢性抽动障碍治疗失败的认知水平。Correctly identifying the treatment failure in chronic tic disorders can prevent the continued use of unnecessary treatments and facilitate timely escalation to experimental or even invasive treatment.However,there is still a lack of a standard definition for the treatment failure in chronic tic disorders.Led by Professor Davide Martino from the University of Calgary in Canada,several rounds of web-based Delphi surveys were conducted to formulate expert clinicians′consensus-based definition for treatment failure in chronic tic disorders.This consensus defines the treatment failure in chronic tic disorders from 4 aspects of behavioral and pharmacological interventions:lack of efficacy,adherence,tolerability and behavioral disorders.In addition,it further defines the failure of behavioral intervention as a whole and pharmacological intervention as a whole.This article interprets the process and key contents of the consensus,and discusses the definition of refractory tic disorders to help clinicians improve their understanding of the treatment failure in chronic tic disorders.

关 键 词：慢性抽动障碍 治疗失败 行为干预 药物治疗 难治性抽动障碍 

分 类 号：R749.94[医药卫生—神经病学与精神病学]