胃癌组织中SOX1与OCT4的交互作用及其对胃癌患者术后复发和生存预后的预测价值  

Interaction between SOX1 and OCT4 in gastric cancer and prediction of postoperative recurrence and survival of gastric cancer patients

作　　者：丁妍冰 柳雨 王克 Ding Yanbing;Liu Yu;Wang Ke(Department of Surgery,the Central Hospital of Nanyang,Nanyang 473000,China)

机构地区：[1]河南省南阳市中心医院外科,473000

出　　处：《临床医学》2024年第8期1-5,共5页Clinical Medicine

摘　　要：目的研究胃癌组织中性别决定区相关高迁移率组盒蛋白1(SOX1)与八聚体结合转录因子4(OCT4)的交互作用及其对胃癌患者术后复发和生存预后的预测价值。方法采用前瞻性研究,选择2018年1月至2019年6月在南阳市中心医院诊断并治疗的94例胃癌患者为研究对象,收集其就诊资料并随访3年生存情况。通过免疫组织化学染色分析患者癌旁组织组与癌组织组、未复发组与复发组、以及生存组与死亡组SOX1与OCT4蛋白水平的差异,并通过Logistic回归分析和ROC曲线研究SOX1与OCT4对胃癌患者复发及死亡的预测效能。结果(1)癌组织组SOX1(t=24.238,P<0.001)与OCT4蛋白表达(t=16.843,P<0.001)显著低于癌旁组织组;复发组SOX1(t=16.565,P<0.001)与OCT4(t=12.444,P<0.001)显著低于未复发组;死亡组SOX1(t=11.759,P<0.001)与OCT4(t=13.854,P<0.001)显著低于生存组。(2)通过Logistic回归分析,SOX1与OCT4蛋白的表达水平与胃癌患者的预后(复发、死亡)密切相关。(3)通过ROC曲线分析,SOX1与OCT4联合诊断对复发以及死亡的曲线下面积高于SOX1、OCT4单独检测,针对复发胃癌患者而言,SOX1与OCT4的截断值分别为0.44、0.35,针对死亡胃癌患者而言,SOX1与OCT4的截断值分别为0.41、0.42,SOX1与OCT4联合诊断对于复发以及死亡的诊断灵敏度与特异度显著高于单独诊断。结论胃癌组织中SOX1与OCT4对胃癌患者术后复发和生存预后具有显著的预测价值,可作为临床诊断以及预后判定的重要参考。Objective To study the interaction between sex-determining region of Y chromosome-related high mobility group box 1(SOX1)and Octamer-binding transcription factor 4(OCT4)in gastric cancer and the prediction of postoperative recurrence and survival of gastric cancer patients.Methods In this prospective study,94 patients with gastric cancer diagnosed and treated in the Central Hospital of Nanyang from January 2018 to June 2019 were selected as the research subjects.The patient's medical information were collected,and the three-year survival of patients was followed-up.Immunohistochemical staining was used to analyze the differences of protein levels of SOX1 and OCT4 between gastric cancer tissues and adjacent tissues,between patients in different recurrence groups,and between patients with different prognosis.Logistic regression analysis and ROC curve were used to study the predictive efficacy of SOX1 and OCT4 protein combined on recurrence and death of gastric cancer patients.Results The protein expression of SOX1(t=24.238,P<0.001)and OCT4(t=16.843,P<0.001)in cancer tissues were significantly lower than those in adjacent tissues;meanwhile,SOX1(t=16.565,P<0.001)and OCT4(t=12.444,P<0.001)protein expressions in the recurrence group were significantly lower than those in the non-recurrence group,and SOX1(t=11.759,P<0.001)and OCT4(t=13.854,P<0.001)protein expressions in the death group were significantly lower than those of the survival group.(2)Through Logistic regression analysis,it was found that the proteins expression level of SOX1 and OCT4 were closely related to prognosis(including recurrence and death)of gastric cancer patients.(3)According to the ROC curve analysis,the area under curve of SOX1 and OCT4 combined diagnosis for recurrence and death was higher than that of SOX1 and OCT4 alone.For patients with recurrent gastric cancer,the cut-off values of SOX1 and OCT4 were 0.44 and 0.35,respectively.For the dead patients,the cut-off values of SOX1 and OCT4 were 0.41 and 0.42,respectively.The combined diagnosis of

关 键 词：胃癌 性别决定区相关高迁移率组盒蛋白1 八聚体结合转录因子4 预测价值 复发 生存 

分 类 号：R735.2[医药卫生—肿瘤]