长链非编码RNA SNHG20在恶性肿瘤中的研究进展  

Research progress of lncRNA SNHG20 in malignant tumors

作　　者：张沁仇 马力 王朝霞[1] ZHANG Qinqiu;MA Li;WANG Zhaoxia(Cancer Medical Center,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China)

机构地区：[1]南京医科大学第二附属医院肿瘤科,江苏南京210011

出　　处：《南京医科大学学报（自然科学版）》2024年第9期1283-1291,共9页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(82072591)。

摘　　要：长链非编码RNA(long non-coding RNA,lncRNA)是一类长度超过200 nt的非编码RNA分子,大量研究报道其在恶性肿瘤的发生发展中发挥重要的生物学功能。近年来,多项研究发现lncRNA小核仁RNA宿主基因20(small nucleolar RNA host gene 20,SNHG20)在肺癌、肝癌、胃癌等多种肿瘤中高表达,促进肿瘤细胞的增殖、迁移、侵袭和上皮间充质转化过程,抑制其凋亡,影响细胞周期进程,且与患者的预后不良相关。作为一个公认的致癌基因,lncRNA SNHG20是恶性肿瘤潜在的治疗靶点和评估预后的生物标志物。文章总结国内外相关研究报道,对lncRNA SNHG20在恶性肿瘤中的研究进展作一综述。Long non-coding RNA(lncRNA)is a class of non-coding RNA molecules with a length of more than 200nt.Numerous studies have reported their significant roles in the occurrence and development of malignant tumors.In recent years,nultiple studies have highlighted the high expression of small nucleolar RNA host gene 20(SNHG20),a type of lncRNA,in various carcinomas such as lung cancer,liver cancer,and gastric cancer.SNHG20 has been shown to promote tumor cell proliferation,migration,invasion and epithelial-mesenchymal transition(EMT),inhibit apoptosis,affect cell cycle progression,and correlate with poor prognosis in patients.As a recognized oncogene,lncRNA SNHG20 is a potential therapeutic target and prognostic biomarker in malignant tumors.In this article,we summarize relevant research reports around the world,and review the research progress of lncRNA SNHG20 in malignant tumors.

关 键 词：lncRNA SNHG20 肿瘤 生物学功能 分子机制 

分 类 号：R730[医药卫生—肿瘤]