线粒体相关内质网膜相关线粒体功能障碍在阿尔茨海默病中的研究进展  

Role of mitochondrial dysfunction associated with mitochondria-associated endoplasmic reticulum membranes in Alzheimer's disease

作　　者：于伟伟 张国高 吴军[2] 胡俊[2] 黄一宁[3] 徐晶 Yu Weiwei;Zhang Guogao;Wu Jun;Hu Jun;Huang Yining;Xu Jing(Department of Chemistry and Shenzhen Grubbs Institute,Guangdong Provincial Key Laboratory of Catalysis,Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis,Southern University of Science and Technology Shenzhen 518055,China;Department of Neurology,Peking University Shenzhen Hospital,Shenzhen 518036,China;Department of Neurology,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]南方科技大学化学系与格拉布斯研究院、广东省催化化学重点实验室、深圳市小分子药物发现和合成重点实验室,深圳518055 [2]北京大学深圳医院神经内科,深圳518036 [3]北京大学第一医院神经内科,北京100034

出　　处：《中华临床医师杂志（电子版）》2024年第2期223-230,共8页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：阿尔茨海默病(AD)是一种进行性神经退行性疾病,临床主要表现为认知功能下降和行为损害,给家庭和社会带来沉重的经济负担。近年来研究发现,线粒体相关内质网膜(MAM)与AD早期病理性改变存在显著相关性,其中包括常见的线粒体功能障碍,即MAM上调可引起细胞内线粒体功能紊乱和结构变化,主要包括线粒体Aβ沉积、线粒体动力学改变和线粒体自噬,进而导致线粒体功能障碍,促进AD发生。本文就MAM介导的线粒体功能障碍在AD病理进程中的作用及机制研究进展进行综述,为早期AD治疗并延缓AD进程提供新的潜在靶点。Alzheimer's disease(AD)is a progressive neurodegenerative disease with clinical manifestations of cognitive dysfunction and behavioral impairment,imposing a heavy economic burden on families and society.Recent studies have revealed that mitochondria-associated endoplasmic reticulum membranes(MAM)have a significant correlation with early pathological changes of AD,such as mitochondrial dysfunction.MAM up-regulation can lead to intracellular mitochondrial dysfunction and structural changes,mainly including mitochondrial Aβdeposition,mitochondrial dynamics alternations,and mitochondrial autophagy,thus promoting the occurrence of AD.This article reviews the role of MAM-mediated mitochondrial dysfunction in the pathological changes of AD,providing new potential targets for the early treatment of AD and the delay of AD progression.

关 键 词：阿尔茨海默病 线粒体相关内质网膜 线粒体Aβ 线粒体动力学 线粒体自噬 

分 类 号：R749.16[医药卫生—神经病学与精神病学]