肝硬化患者门静脉血栓形成的影响因素  

Influencing factors of portal vein thrombosis in patients with liver cirrhosis

作　　者：李慧国 杨道坤[2] LI Huiguo;YANG Daokun(Department of Digestive Medicine of Nanchang Ninth Hospital,Nanchang 330046 Jiangxi,China;Third Department of Infection of the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453199 Henan,China)

机构地区：[1]南昌市第九医院消化内科,江西南昌330046 [2]新乡医学院第一附属医院感染三科,河南新乡453199

出　　处：《中国民康医学》2024年第17期17-20,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析肝硬化患者门静脉血栓形成的影响因素。方法:选取2018年11月至2023年11月于南昌市第九医院就诊的116例肝硬化患者进行横断面研究,根据影像学检查结果分为血栓组与非血栓组,收集两组临床资料,分析肝硬化患者门静脉血栓形成的影响因素。结果:116例肝硬化患者中,40例形成门静脉血栓,发生率为34.48%(40/116);两组性别、年龄、肝硬化病因、吸烟史、合并高血压、体质量指数、Child-Pugh分级比较,差异均无统计学意义(P>0.05);两组合并糖尿病、D-二聚体(D-D)水平、C反应蛋白/白蛋白比值(CAR)、全身免疫炎症反应指数(SII)、门静脉宽度比较,差异均有统计学意义(P<0.05);Logistic回归分析结果显示,合并糖尿病、D-D≥2.5 mg/L、SII≥500×10^(9)/L、门静脉宽度≥15 mm均为肝硬化患者门静脉血栓形成的危险因素(P<0.05)。结论:合并糖尿病、D-D≥2.5 mg/L、SII≥500×10^(9)/L、门静脉宽度≥15 mm均为肝硬化患者门静脉血栓形成的危险因素。Objective:To analyze influencing factors of portal vein thrombosis in patients with cirrhosis.Methods:A cross-sectional study was conducted on 116 patients with liver cirrhosis who were admitted to Nanchang Ninth Hospital from November 2018 to November 2023.According to the results of imaging examination,they were divided into thrombus group and non-thrombus group.The clinical data of the two groups were collected.The influencing factors of portal vein thrombosis in these patients with cirrhosis were analyzed.Results:Among the 116 patients with cirrhosis,40 cases suffered from portal vein thrombosis,and the incidence rate was 34.48%(40/116).There were no significant differences in gender,age,etiology of cirrhosis,smoking history,combined hypertension,body mass index and Child-Pugh classification between the two groups(P>0.05).There were significant differences in combined diabetes mellitus,D-dimer(D-D)level,C-reactive protein to albumin ratio(CAR),systemic immune inflammatory response index(SII)and portal vein width between the two groups(P<0.05).Logistic regression analysis showed that combined diabetes mellitus,D-D≥2.5 mg/L,SII≥500×10^(9)/L and portal vein width≥15 mm were risk factors for portal vein thrombosis in the patients with cirrhosis(P<0.05).Conclusions:Combined diabetes mellitus,D-D≥2.5 mg/L,SII≥500×10^(9)/L,and portal vein width≥15 mm are the risk factors for portal vein thrombosis in the patients with cirrhosis.

关 键 词：肝硬化 门静脉血栓 糖尿病 门静脉宽度 影响因素 

分 类 号：R575.2[医药卫生—消化系统]