血清CYFRA21-1、NSE、VEGF水平联合检测对肺癌患者淋巴结转移的诊断价值  

Diagnostic value of combined detection of serum CYFRA21-1,NSE and VEGF levels for lymph node metastasis in patients with lung cancer

作　　者：王朝鑫 WANG Chaoxin(Department of Clinical Laboratory of Pingdingshan Medical Area of 989th Hospital of PLA Joint Logistics Support Force,Pingdingshan 467000 Henan,China)

机构地区：[1]解放军联勤保障部队第九八九医院平顶山医疗区检验科,河南平顶山467000

出　　处：《中国民康医学》2024年第17期127-129,133,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨血清细胞角蛋白19片段抗原21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、血管内皮生长因子(VEGF)水平联合检测对肺癌患者淋巴结转移的诊断价值。方法:回顾性分析2020年1月至2022年12月该院收治的150例肺癌患者的临床资料。根据是否发生淋巴结转移将其分为转移组(n=52)与未转移组(n=98)。比较两组患者的病理分型、临床分期和血清CYFRA21-1、NSE、VEGF水平,以及不同临床分期患者的血清CYFRA21-1、NSE、VEGF水平。采用受试者工作特征(ROC)曲线分析血清CYFRA21-1、NSE、VEGF水平单项及联合检测对肺癌淋巴结转移的诊断价值。结果:转移组小细胞肺癌占比、临床分期及血清CYFRA21-1、NSE、VEGF水平均高于未转移组,且患者临床分期越高,血清CYFRA21-1、NSE、VEGF水平越高,差异有统计学意义(P<0.05);ROC曲线分析结果显示,血清CYFRA21-1、NSE、VEGF水平单项及联合检测诊断肺癌淋巴结转移的曲线下面积分别为0.873、0.828、0.701、0.954,联合检测诊断价值高于单一指标检测。结论:血清CYFRA21-1、NSE、VEGF水平检测对肺癌淋巴结转移具有较高的诊断价值,且联合检测的诊断价值高于单项指标检测。Objective:To investigate diagnostic value of combined detection of serum cyto-keratin 19 fragment antigen 21-1(CYFRA21-1),neuron-specific enolase(NSE)and vascular endothelial growth factor(VEGF)levels for lymph node metastasis in patients with lung cancer.Methods:The clinical data of 150 patients with lung cancer admitted to this hospital from January 2020 to December 2022 were retrospectively analyzed.According to whether lymph node metastasis occurred,they were divided into metastasis group(n=52)and non-metastasis group(n=98).The pathological type,the clinical stage and the serum levels of CYFRA21-1,NSE and VEGF were compared between the two groups.Further,the serum levels of CYFRA21-1,NSE and VEGF in the patients with different clinical stage were also compared.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of single and combined detection of serum CYFRA21-1,NSE and VEGF levels for lymph node metastasis in the patients with lung cancer.Results:The proportion of small cell carcinoma,the clinical stage and the serum CYFRA21-1,NSE and VEGF levels in the metastasis group were higher than those in the non-metastasis group;the higher the clinical stage was,the higher the levels of serum CYFRA21-1,NSE and VEGF were;and the differences were statistically significant(P<0.05).ROC curve analysis showed that the area under the curve of single and combined detection of serum CYFRA21-1,NSE and VEGF levels in the diagnosis of lymph node metastasis in the patients with lung cancer was 0.873,0.828,0.701 and 0.954,respectively,and the diagnostic value of combined detection was higher than that of single detection.Conclusions:The detection of the serum CYFRA21-1,NSE and VEGF levels has high diagnostic value for lymph node metastasis in the patients with lung cancer,and the diagnostic value of combined detection is higher than that of single detection.

关 键 词：细胞角蛋白19片段抗原21-1 神经元特异性烯醇化酶 血管内皮生长因子 肺癌 淋巴结转移 诊断 

分 类 号：R734.2[医药卫生—肿瘤]