封闭负压引流技术(VSD)对口腔颌面部多间隙感染患者促炎及创面愈合相关因子的影响  

The Impact of VSD Negative Pressure Drainage on Pro-Inflammatory and Wound Healing-Related Factors in Patients with Multi-Space Infections of the Oral and Maxillofacial Region

作　　者：周云龙 胡江[2] ZHOU Yunlong;HU Jiang(Department of Stomatology,Xinyang Central Hospital,Xinyang Henan 464000,China;Department of Stomatology,The Affiliated Hospital of Jilin Medical University.,Jilin Jilin 132000,China)

机构地区：[1]信阳市中心医院口腔科,河南信阳464000 [2]吉林医药学院附属医院口腔科,吉林吉林132000

出　　处：《临床研究》2024年第9期30-33,共4页Clinical Research

摘　　要：目的探讨封闭负压引流技术(VSD)对口腔颌面部多间隙感染患者促炎及创面愈合相关因子的影响。方法将2021年1月至2023年1月信阳市中心医院诊治的60例口腔颌面部多间隙感染患者按随机数表法分两组,各30例。对照组进行常规切开引流,研究组进行VSD负压引流,对两组临床疗效及治疗前后创面疼痛程度、促炎因子[白介素-6(IL-6)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)]、创面愈合相关因子[血小板源性生长因子(PDGF)、表皮细胞生长因子(EGF)、转化生长因子-β(TGF-β)]、临床指标(脓肿最大径、张口度)进行统计学分析。结果研究组治疗有效率(96.67%)高于对照组(73.33%),差异具有统计学意义(P<0.05)。两组治疗后1 d、3 d、7 d时视觉模拟评分(VAS)均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。两组治疗后IL-6、PCT及TNF-α水平低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。两组治疗后PDGF水平低于治疗前,且研究组低于对照组,而EGF、TGF-β水平高于治疗前,且研究组高于对照组,差异均有统计学意义(P<0.05)。两组治疗后脓肿最大径低于治疗前,且研究组低于对照组,而张口度高于治疗前,且研究组高于对照组,差异均有统计学意义(P<0.05)。结论对口腔颌面部多间隙感染患者采用VSD负压引流治疗可有效减轻创面疼痛程度,抑制促炎因子表达,改善创面愈合相关因子水平,促进创面修复,疗效显著。Objective To explore the impact of vacuum sealing drainage(VSD)on pro-inflammatory and wound healing-related factors in patients with multi-space infections of the oral and maxillofacial region.Methods From January 2021 to January 2023,60 patients with multi-space infections of the oral and maxillofacial region treated at Xinyang Central Hospital were randomly divided into two groups,with 30 cases in each group.The control group received conventional incision and drainage,while the study group received VSD negative pressure drainage.Clinical efficacy,wound pain levels before and after treatment,pro-inflammatory factors[interleukin-6(IL-6),procalcitonin(PCT),tumor necrosis factor-alpha(TNF-α)],wound healing-related factors[platelet-derived growth factor(PDGF),epidermal growth factor(EGF),transforming growth factor-beta(TGF-β)],and clinical indicators(maximum abscess diameter,mouth opening)were statistically analyzed for both groups.Results The treatment efficacy in the study group(96.67%)was higher than that in the control group(73.33%),with statistically significant differences(P<0.05).The visual analog scale(VAS)scores at 1 day,3 days,and 7 days after treatment were lower than before treatment in both groups,and the scores in the study group were lower than those in the control group,with statistically significant differences(P<0.05).The levels of IL-6,PCT,and TNF-αafter treatment were lower than before treatment in both groups,and the levels in the study group were lower than those in the control group,with statistically significant differences(P<0.05).The levels of PDGF after treatment were lower than before treatment in both groups,and the levels in the study group were lower than those in the control group,while the levels of EGF and TGF-βwere higher than before treatment in both groups,and the levels in the study group were higher than those in the control group,with statistically significant differences(P<0.05).The maximum abscess diameter after treatment was lower than before treatment in both groups,

关 键 词：口腔 颌面部 多间隙感染 VSD负压引流 促炎因子 创面愈合相关因子 

分 类 号：R782.3[医药卫生—口腔医学]