全视网膜光凝术联合药物治疗糖尿病视网膜病变的临床研究  

Clinical Study on Panretinal Photocoagulation Combined with Medication for Diabetic Retinopathy

作　　者：袁怡 YUAN Yi(Department of Ophthalmology,Nanyang Second People’s Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市第二人民医院眼科,河南南阳473000

出　　处：《临床研究》2024年第9期44-47,共4页Clinical Research

摘　　要：目的探究全视网膜光凝术(PRP)联合抗血管内皮生长因子(VEGF)药物对糖尿病视网膜病变(DR)的治疗效果。方法选取2023年1月至2023年12月南阳市第二人民医院收治的89例DR患者作为研究对象,按随机数字表法将之分为对照组(44例,78眼)与研究组(45例,81眼),对照组给予PRP治疗,研究组给予抗VEGF药物+PRP治疗。比较两组疗效、最佳矫正视力(BCVA)、中央黄斑厚度(CMT)、视网膜微血管病变程度及血液流变学指标。结果研究组治疗有效率高于对照组,差异具有统计学意义(P<0.05)。术前与术后2周,两组BCVA与CMT水平比较,差异无统计学意义(P>0.05);术后4周、6周、12周,研究组BCVA水平高于对照组,CMT水平低于对照组,差异均有统计学意义(P<0.05);研究组术后2周的CMT水平低于术前,两组术后4周、6周、12周的BCVA均高于术前与术后2周,CMT均低于术前与术后2周,差异有统计学意义(P<0.05)。术前,两组视网膜微血管病变程度差异无统计学意义(P>0.05);与同组术前相比,术后12周微血管瘤数量、渗出灶与出血灶面积均减少,且研究组低于对照组,差异均有统计学意义(P<0.05)。术前,两组血液流变学指标差异无统计学意义(P>0.05);术后12周两组全血黏度、血浆黏度及红细胞沉降率均降低,且研究组低于对照组,差异均有统计学意义(P<0.05)。结论抗VEGF药物联合PRP对DR的疗效显著,可改善患者术后视力与中央黄斑厚度,缓解视网膜微血管病变程度,调节机体血液流变学状况。Objective To investigate the therapeutic effect of panretinal photocoa gulation(PRP)combined with antivascular endothelial growth factor(VEGF)drugs on diabetic retinopathy(DR).Methods A total of 89 DR patients treated at Nanyang Second People’s Hospital from January 2023 to December 2023 were selected as research subjects.They were randomly divided into a control group(44 cases,78 eyes)and a study group(45 cases,81 eyes)using a random number table method.The control group received PRP treatment,while the study group received anti-VEGF drugs combined with PRP treatment.The efficacy,best-corrected visual acuity(BCVA),central macular thickness(CMT),degree of retinal microvascular lesions,and hemorheological indicators were compared between the two groups.Results The effective rate of treatment in the study group was higher than that in the control group,with a statistically significant difference(P<0.05).There was no statistically significant difference in BCVA and CMT levels between the two groups before and 2 weeks after surgery(P>0.05).At 4,6,and 12 weeks after surgery,the BCVA level in the study group was higher than that in the control group,and the CMT level was lower than that in the control group,with statistically significant differences(P<0.05).The CMT level in the study group was lower than before surgery at 2 weeks after surgery.The BCVA levels in both groups at 4,6,and 12 weeks after surgery were higher than before surgery and 2 weeks after surgery,and the CMT levels were lower than before surgery and 2 weeks after surgery,with statistically significant differences(P<0.05).There was no statistically significant difference in the degree of retinal microvascular lesions between the two groups before surgery(P>0.05).Compared with the same group before surgery,the number of microaneurysms,exudation foci,and hemorrhage areas decreased at 12 weeks after surgery,and the study group was lower than the control group,with statistically significant differences(P<0.05).There was no statistically significant diffe

关 键 词：糖尿病视网膜病变 全视网膜光凝术 血管内皮生长因子 中央黄斑厚度 血液流变学 

分 类 号：R774.1[医药卫生—眼科]