Physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer  

作　　者：Zhi-Wen Luo Ya-Ying Sun Wei Xia Jun-Ying Xu Dong-Jing Xie Chun-Meng Jiao Ji-Ze Dong Hui Chen Ren-Wen Wan Shi-Yi Chen Jie Mei Wen-Jun Mao 

机构地区：[1]Department of Sports Medicine,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China [2]Department of Sports Medicine,Shanghai General Hospital,Shanghai 200080,China [3]Department of Critical Care Medicine,the Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214023,Jiangsu,China [4]Department of Oncology,the Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214023,Jiangsu,China [5]Guangdong Pharmaceutical University,Guangzhou 510006,China [6]Institute of Acupuncture Research,Institutes of Integrative Medicine,Fudan University,Shanghai 200433,China [7]Department of Cardiothoracic Surgery,the Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214023,Jiangsu,China

出　　处：《Military Medical Research》2024年第4期616-619,共4页军事医学研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(82172511);the Natural Science Foundation of Jiangsu Province(BK20210068);the Sanming Project of Medicine in Shenzhen(SZSM201612078);the Health Shanghai Initiative Special Fund[Medical-Sports Integration(JKSHZX-2022-02)];the Top Talent Support Program for Young-and Middle-aged People of Wuxi Municipal Health Commission(HB2020003);the Mega-project of Wuxi Commission of Health(Z202216);the High-end Medical Expert Team of the 2019 Taihu Talent Plan(2019-THRCTD-1)

摘　　要：Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are obscure.Immunometabolic regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer[1,2].Physical exercise primarily lowers blood cholesterol and triglycerides,and protects against cardiovascular diseases[3].However,whether physical exercise can modulate cholesterol metabolism in tumor cells is currently unknown.

关 键 词：Physical exercise Non-small cell lung cancer(NSCLC) Squalene epoxidase(SQLE) Tumor immune microenvironment(TIME) 

分 类 号：R734.2[医药卫生—肿瘤]