青春期前型睾丸神经内分泌瘤1例报告  

Prepubertal-type testicular neuroendocrine tumor:a case report

作　　者：张馨文 周晓莉 顾文贤 李婷 程羽青 Zhang Xinwen;Zhou Xiaoli;Gu Wenxian;Li Ting;Cheng Yuqing(Department of Pathology,the Affiliated Jintan Hospital of Jiangsu University Changzhou Jintan First people's Hospital,Changzhou 213200,China;Department of Pathology,the Afiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213003,China)

机构地区：[1]江苏大学附属金坛医院,常州市金坛第一人民医院病理科,常州213200 [2]南京医科大学附属常州第二人民医院病理科,常州213003

出　　处：《中华泌尿外科杂志》2024年第8期635-636,共2页Chinese Journal of Urology

基　　金：常州市科技局社会发展项目(CE20235064)。

摘　　要：青春期前型睾丸神经内分泌瘤是罕见的睾丸低度恶性肿瘤,属于与原位生殖细胞肿瘤无关的生殖细胞肿瘤,需与转移性神经内分泌瘤、青春期后型睾丸神经内分泌瘤等鉴别。本文报道1例青春期前型睾丸神经内分泌瘤,肿瘤细胞大小一致,排列成巢状、岛状。免疫组化染色检查示CgA、Syn阳性,Ki-67指数<2%阳性,二代测序检查未发现具有明确、潜在或尚不明确临床意义的变异。术后随访56个月,肿瘤无复发、转移。Prepubertal-type testicular neuroendocrine tumor is a rare neoplasm of low malignant potential,which is classified as germ cell tumors unrelated to germ cell neoplasia in situ,and needs to be differentiated from metastatic neuroendocrine tumor,postpubertal-type testicular neuroendocrine tumor,and testicular seminoma.The clinicopathological and molecular features of a case of prepubertal-type testicular neuroendocrine tumor were reported.The tumour cells were uniform in size and arranged in nested and insular pattern.The tumor was positive for CgA and Syn,and the Ki-67 index was less than 2%by immunostaining.Next-generation sequencing identified no variants of pathogenicity,potential pathogenicity or uncertain significance.The patient was followed without evidence of recurrence and metastasis 56 months after surgery.

关 键 词：睾丸肿瘤 青春期前型睾丸神经内分泌瘤 病理 

分 类 号：R737.21[医药卫生—肿瘤]