葡萄柚提取物柚皮素对运动性心肌损伤中铁死亡的调节作用  

Regulatory Role of Aglycone Naringenin from Grapefruit Extract on Ferroptosis in Exercise-Induced Myocardial Injury

作　　者：邵语平[1] Shao Yuping(School of Physical Education and Health,Longnan Teachers College,Longnan,742500)

机构地区：[1]陇南师范高等专科学校体育与健康学院,陇南742500

出　　处：《分子植物育种》2024年第17期5825-5833,共9页Molecular Plant Breeding

基　　金：甘肃省教育科学“十四五”规划课题项目(GS[2021]GHB1829)资助。

摘　　要：葡萄柚(Grapefruit)中含有丰富的无糖体柚皮素(aglycone naringenin,NAR),以其抗氧化、抗炎、抗癌、心血管保护和抗糖尿病的潜在效果而被广泛研究,它可以直接参与多种生物化学途径,调节酶活性和细胞信号传递。本研究旨在探索葡萄柚提取物中的无糖体柚皮素(NAR)如何通过调节ROS/GSH/GPX4轴来对抗EIMI中的铁死亡。通过系列实验,本研究证实无糖体柚皮素能有效减少心肌中活性氧(ROS)的生成,并通过提高谷胱甘肽(GSH)和谷胱甘肽过氧化物酶4(GPX4)的活性,来抑制铁死亡,从而保护心肌免受过度运动引起的损伤。此外,柚皮素还显示出调节核因子-红细胞因子2相关因子2(Nrf2)/System xc-轴的潜力,进一步增强心肌细胞的抗氧化防御能力。本研究结果表明,无糖体柚皮素是一种潜在的EIMI治疗剂,为进一步开发基于天然产物的心肌保护策略提供了科学依据。Naringenin(NAR),an aglycone flavonoid abundant in grapefruit,has been extensively studied for its potential antioxidative,anti-inflammatory,anticancer,cardiovascular protective,and antidiabetic effects.It actively participates in various biochemical pathways,regulating enzymatic activity and cell signaling.This study aims to explore how naringenin in grapefruit extract counteracts ferroptosis in exercise-induced myocardial injury(EIMI)through the regulation of the ROS/GSH/GPX4 axis.Through a series of experiments,we confirmed that naringenin effectively reduces the production of reactive oxygen species(ROS)in the myocardium and inhibits ferroptosis by enhancing the activity of glutathione(GSH)and glutathione peroxidase 4(GPX4),thereby protecting the myocardium from damage caused by excessive exercise.Additionally,naringenin also demonstrates the potential to regulate the nuclear factor erythroid 2-related factor 2(Nrf2)/System xc-axis,further enhancing the antioxidative defense capabilities of myocardial cells.The findings of this study suggest that naringenin is a potential therapeutic agent for EIMI,providing a scientific basis for the further development of natural product-based strategies for myocardial protection.

关 键 词：葡萄柚 无糖体柚皮素(aglycone naringenin NAR) 运动性心肌损伤 铁死亡 ROS/GSH/GPX4轴 心肌保护 

分 类 号：TS201.4[轻工技术与工程—食品科学] R285[轻工技术与工程—食品科学与工程]