精神分裂症患者合并腹型肥胖对认知障碍影响的研究进展  

Research progress on the effect of schizophrenia complicated by abdominal obesity on cognitive impairment

作　　者：苏宇静 俞天悦 陈剑华[1] Su Yujing;Yu Tianyue;Chen Jianhua(Shanghai Clinical Research Center for Mental Health,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心、上海市精神心理疾病临床医学研究中心,200030

出　　处：《神经疾病与精神卫生》2024年第8期589-594,共6页Journal of Neuroscience and Mental Health

基　　金：国家自然科学基金(82071500);上海市中医药传承创新发展计划[ZY-(2021-2023)-0207-01];上海市科技创新行动计划(21Y11921100);上海市优秀学术/技术带头人计划(21XD1423300);上海市浦江计划(2021PJD063)。

摘　　要：精神分裂症是一种严重的精神疾病,以认知障碍为核心症状之一。腹型肥胖等代谢并发症在精神分裂症患者中广泛存在,不仅增加了患者的心血管疾病风险,同时也与认知障碍,尤其是注意力、记忆力和执行功能的损害相关。精神分裂症合并腹型肥胖可能通过多种机制共同影响患者认知功能,如激发慢性炎性反应、胰岛素抵抗以及影响肠道菌群的构成,从而进一步加剧认知障碍。本文综述精神分裂症患者合并腹型肥胖的危险因素以及影响认知障碍的潜在机制和治疗策略,并展望未来研究方向,以期为改善精神分裂症患者的腹型肥胖和认知障碍提供理论依据。Schizophrenia is a serious mental disorder characterized by cognitive impairment as one of its core symptoms.Metabolic complications such as abdominal obesity are widespread in patients with schizophrenia.This not only elevates the risk of cardiovascular disease in patients,but is also associated with cognitive deficits,particularly impairments in attention,memory,and executive function.Studies have shown that combined abdominal obesity in schizophrenia may affect cognitive function through multiple mechanisms,such as triggering chronic inflammatory responses,insulin resistance,and influencing the composition of the gut flora,which may further exacerbate cognitive impairment.This article describes the risk factors for combined abdominal obesity in schizophrenia,as well as the potential mechanisms and treatment strategies affecting cognitive impairment,and looks forward to future research directions,with a view to providing a theoretical basis for improving abdominal obesity and cognitive impairment in schizophrenia.

关 键 词：精神分裂症 认知障碍 腹型肥胖 非典型抗精神病药物 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R589.2[医药卫生—临床医学]