肝癌分子影像诊疗现状及最新进展  

Current status and new advancements in molecular imaging of liver cancer

作　　者：常娣 杨洁 李迎波 周昕宇 居胜红[1] Chang Di;Yang Jie;Li Yingbo;Zhou Xinyu;Ju Shenghong(Department of Radiology,Zhongda Hospital,Medical School of Southeast University,Nurturing Center of Jiangsu Province for State Laboratory of Al Imaging&Interventional Radiology(Southeast University),Nanjing 210009,China;Medical School of Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学附属中大医院放射科智能影像与介入医学国家级重点实验室培育建设点(东南大学),南京210009 [2]东南大学医学院,南京210009

出　　处：《中华肝脏病杂志》2024年第8期688-694,共7页Chinese Journal of Hepatology

基　　金：国家自然科学基金项目(92359304、82330060、92059202、82372024);国家重点研发计划(2021YFF0501504、2021YFA1101304)。

摘　　要：肝癌早期诊断困难,总体预后不佳。肝癌在群体间与个体内存在高度异质性,肿瘤微环境复杂,活体、动态解析肝癌微环境中的生物学标志物具有重要意义。近年来,随着分子影像学的发展,肝癌的影像诊疗取得了显著进展。分子影像技术利用特定的纳米成像探针,能够在体实时评价肝癌分子、细胞水平的病理变化,以特异性成像精准揭示肝癌发生、演进过程中的关键分子标志物,探究其与肝癌进展、转归的关联。现以分子影像为切入点,着重阐述CT、MRI、光学成像、正电子发射体层成像和多模态成像等分子影像技术在肝癌影像诊疗领域的研究现状及取得的最新进展,并指出未来发展的重要方向及重大挑战。Early-stage diagnosis of liver cancer is challenging,with an overall poor prognosis.The tumor microenvironment of primary liver cancer is complex,exhibiting significant heterogeneity both interpersonally and intratumorally.Therefore,it is of paramount importance to dynamically analyze biological markers in the tumor microenvironment of primary liver cancer in vivo.In recent years,significant progress has been made in the imaging diagnosis and treatment of liver cancer with the development of molecular imaging.Molecular imaging techniques utilize specific nano-imaging probes to evaluate pathological changes of liver cancer at the molecular and cellular levels in real-time.These techniques enable precise imaging to reveal key molecular biomarkers involved in the occurrence and progression of liver cancer,exploring their associations with cancer progression and outcomes.This article focuses on molecular imaging,emphasizing the current research status and latest advancements in the field of liver cancer diagnosis and therapy using techniques such as CT,MRI,optical imaging,PET imaging,and multimodal imaging.It also identifies important future directions and significant challenges for further development.

关 键 词：肝癌 分子影像 活体成像 成像引导下的治疗 诊断 治疗 

分 类 号：R735.7[医药卫生—肿瘤] R445[医药卫生—临床医学]