中性粒细胞的异质性和多潜能性在肿瘤进展中的作用  

Heterogeneity and Pluripotency of Neutrophils in the Progression of Tumors

作　　者：李玫颖 曹邦荣 梁胜梅 马士淇[1] Li Meiying;Cao Bangrong;Liang Shengmei;Ma Shiqi(Department of Experimental Research,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospi-tal&Institute,Sichuan Cancer Center,Afiliated Cancer Hospital of University of Electronic Science and Technology of China,Chengdu 610041,Sichuan,China)

机构地区：[1]四川省肿瘤临床医学研究中心,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院实验研究部,成都610041

出　　处：《肿瘤预防与治疗》2024年第8期698-704,共7页Journal of Cancer Control And Treatment

基　　金：国家自然科学基金青年项目(编号:82303645)。

摘　　要：中性粒细胞是人类血液中最丰富的髓系细胞,在肿瘤发生和发展中发挥着潜在的作用。中性粒细胞具有短暂生命周期、终末分化和非增殖性等特性,其对肿瘤进展相关的意义需要深入了解。近年来,多项研究发现,中性粒细胞在肿瘤微环境中具有异质性和多潜能性特征。本文综述了中性粒细胞的异质性和多潜能性对肿瘤进展的影响因素及其与肿瘤细胞的互作,为靶向中性粒细胞的肿瘤治疗策略提供一个潜在的理论依据。Neutrophils are the most abundant myeloid cells in human blood and play a potential role in the occurrence and development of tumors.Neutrophils are characterized by a short life span,terminal differentiation,and non-proliferative properties,and their significance for tumor progression requires further investigating.In recent years,multiple studies have found that neutrophils exhibit heterogeneity and multipotency within the tumor microenvironment.This review summarizes the factors affecting tumor progression due to the heterogeneity and multipotency of neutrophils and their interaction with tumor cells,providing a potential theoretical basis for tumor treatment strategies targeting neutrophils.

关 键 词：中性粒细胞 肿瘤微环境 异质性 多潜能性 

分 类 号：R730.231[医药卫生—肿瘤]