血清TFF2、PGRN、hs-CRP水平在胃溃疡患者疗程中的变化及临床价值  

Changes in serum TFF2,PGRN and hs-CRP in patients with gastric ulcer during treatment and their clinical values

作　　者：靳华锋 陈晓琦 李静 JIN Hua-feng;CHEN Xiao-qi;LI Jing

机构地区：[1]郑州市惠济区人民医院消化内科,河南郑州450000 [2]郑州大学第三附属医院儿童发育行为科,河南郑州450000

出　　处：《中国疗养医学》2024年第10期94-97,共4页Chinese Journal of Convalescent Medicine

摘　　要：目的观察胃溃疡患者治疗过程中血清三叶因子2(TFF2)、颗粒蛋白前体(PGRN)、超敏C反应蛋白(hs-CRP)水平变化,并探究其对疗效的预测价值。方法回顾性选取2021年6月至2023年6月于郑州市惠济区人民医院诊治的93例胃溃疡患者为研究对象,依据治疗6周后疗效分为有效组71例、无效组22例,比较两组治疗前及治疗1周、3周、6周后血清TFF2、PGRN、hs-CRP水平。比较两组临床资料并分析疗效的影响因素。评价治疗3周后血清TFF2、PGRN、hs-CRP水平对治疗6周后疗效的预测价值。结果无效组治疗1周、3周、6周后血清TFF2水平低于有效组,血清PGRN、hs-CRP水平高于有效组(P<0.05);血清TFF2水平为无效的保护因素,血清PGRN、hs-CRP水平为无效的危险因素(P<0.05);治疗3周后血清TFF2、PGRN、hs-CRP水平单项及联合预测治疗6周后疗效的AUC分别为0.799、0.763、0.794、0.906,且联合预测的AUC明显大于单项指标预测(P<0.05)。结论胃溃疡治疗无效者血清TFF2水平降低,PGRN、hs-CRP水平升高,且为疗效的影响因素,联合检测其水平对疗效具有一定预测价值。Objective To observe the changes in serum trefoil factor 2(TFF2),progranulin(PGRN)and highsensitivity C-reactive protein(hs-CRP)in patients with gastric ulcer during treatment,and to explore their predictive value in curative effect.Methods A total of 93 patients with gastric ulcer treated in Huiji District People's Hospital from June 2021 to June 2023 were retrospectively selected as the research objects.According to the curative effect after 6 weeks of treatment,they were divided into the effective group(71 cases)and the ineffective group(22 cases).Serum levels of TFF2,PGRN and hs-CRP were compared between the two groups before treatment and at weeks 1,3 and 6 of treatment.The clinical data of the two groups were compared and the influencing factors of the curative effect were analyzed.The predictive value of the serum TFF2,PGRN and hs-CRP at week 3 for the 6-week curative effect was evaluated.Results After weeks 1,3 and 6 weeks of treatment,serum TFF2 level in the ineffective group was significantly lower than that of the effective group,but serum PGRN and hs-CRP levels were significantly higher(P<0.05).Serum TFF2 was an ineffective protective factor,while serum PGRN and hs-CRP were ineffective risk factors for curative effect(P<0.05).The area under the curve(AUC)of serum TFF2,PGRN,and hs-CRP,and their combination at week 3 of treatment in predicting the 6-week curative effect was 0.799,0.763,0.794,and 0.906,respectively.The AUC of the combination in predicting the curative effect was significantly greater than that of each single index(P<0.05).Conclusion Serum TFF2 decreases,and serum PGRN and hs-CRP increase in patients with ineffective treatment of gastric ulcer,which are the influencing factors of curative effect.The combined detection has a certain predictive value in the curative effect.

关 键 词：胃溃疡 三叶因子2 颗粒蛋白前体 超敏C反应蛋白 疗效 

分 类 号：R573.1[医药卫生—消化系统]