术前血清NF⁃κB、NLRP3水平对脑胶质瘤切除术患者的预后预测价值  

Prognostic value of preoperative serum NF⁃κB and NLRP3 levels in patients undergoing glioma resection

作　　者：武通帅 刘震洋 WU Tongshuai;LIU Zhenyang(Department of Neurosurgery,Shanxi Bethune Hospital/Shanxi Academy of Medical Sciences/Tongji Shanxi Hospital/Third Hospital of Shanxi Medical University,Taiyuan 030032,China)

机构地区：[1]山西白求恩医院/山西医学科学院/同济山西医院/山西医科大学第三医院神经外科,山西太原030032

出　　处：《中国肿瘤外科杂志》2024年第4期344-348,共5页Chinese Journal of Surgical Oncology

基　　金：山西省科学技术厅(202204021301001)。

摘　　要：目的探究术前血清核因子⁃κB(NF⁃κB)、核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)水平对脑胶质瘤切除术患者的预后预测价值。方法选取2020年1月至2023年1月山西白求恩医院收治的80例脑胶质瘤切除术患者为研究对象,随访1年,根据有无复发、死亡等预后情况分为预后良好组(63例)和预后不良组(17例)。对比两组患者术前血清NF⁃κB、NLRP3水平,采用多因素Logistic回归分析影响脑胶质瘤切除术患者预后的影响因素,并绘制受试者工作特征曲线(ROC)评估血清NF⁃κB、NLRP3水平对脑胶质瘤切除术患者预后的预测价值。结果预后不良组患者年龄、肿瘤最大径、肿瘤分级、血清NF⁃κB、NLRP3水平与预后良好组患者相比,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,年龄、肿瘤最大径、肿瘤分级、血清NF⁃κB、NLRP3水平均为脑胶质瘤切除术患者预后不良的危险因素(P<0.05)。ROC曲线分析结果显示,单一术前血清NF⁃κB、NLRP3水平及两者联合预测脑胶质瘤切除术患者预后不良的曲线下面积分别为0.734、0.746、0.812,特异度分别为68.91%、72.21%、78.63%,灵敏度分别为75.62%、73.05%、80.68%。结论术前血清NF⁃κB、NLRP3水平与脑胶质瘤切除术患者预后不良有关,可用于预测脑胶质瘤切除术患者的预后,且两项指标联合具有较好的预测效能。Objective To investigate the prognostic value of preoperative serum levels of nuclear factor kappa⁃B(NF⁃κB)and Nod⁃like receptor pyrin domain 3(NLRP3)in patients undergoing glioma resection.Methods 80 patients undergoing glioma resection in Shanxi Bethune Hospital from January 2020 to January 2023 were selected as the study objects.The patients were followed up for 1 year and divided into a good prognosis group(63 cases)and a poor prognosis group(17 cases)according to the prognosis.The levels of NF⁃κB and NLRP3 in serum before operation were compared between the two groups.A multi⁃factorial Logistic regression was conducted to identify factors influencing the prognosis of patients undergoing glioma resection.Receiver operating characteristic curve(ROC)was drawn to evaluate the predicative value of serum NF⁃κB and NLRP3 levels in patients with glioma resection.Results There In the poor prognosis group,patient’s age,maximum tumor diameter,tumor grading,serum levels of NF⁃κB and NLRP3 was significantly different compared to the good prognosis group(P<0.05).Multivariate Logistic regression analysis revealed that age,maximum tumor diameter,tumor grading,serum levels of NF⁃κB and NLRP3 were risk factors for poor prognosis in patients undergoing glioma resection(P<0.05).ROC curve analysis indicated that the area under the curve for predicting poor prognosis in glioma resection patients using preoperative single serum NF⁃κB,NLRP3 levels,and their combination were 0.734,0.746 and 0.812,respectively.The specificity was 68.91%,72.21%and 78.63%,respectively.The sensitivity was 75.62%,73.05%and 80.68%,respectively.Conclusions Preoperative serum NF⁃κB and NLRP3 levels are associated with poor prognosis in patients undergoing glioma resection.They can be used to predict the prognosis of patients undergoing glioma resection,and the combination of the two indexes has a good predictive effect.

关 键 词：核因子⁃κB Nod样受体蛋白⁃3 脑胶质瘤切除术 预后 

分 类 号：R739.4[医药卫生—肿瘤]