脑小血管病早期诊断与靶向干预研究新进展  

Recent advance in early diagnosis and targeted intervention of cerebral small vascular disease

作　　者：王羽涵 徐运[1] 张清秀 Wang Yuhan;Xu Yun;Zhang Qingxiu(Department of Neurology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院神经内科,南京210008

出　　处：《中华神经医学杂志》2024年第8期848-853,共6页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金重点项目(82130036);国家自然科学基金面上项目(82371327、82071304)。

摘　　要：脑小血管病(CSVD)是由颅内小血管病变引起的临床综合征,病因和发病机制复杂,目前临床尚缺乏早期诊断和特异性治疗方法。本文总结近年来CSVD动物模型制备方法,对CSVD早期诊断的影像学和生物学标志物进行梳理,并进一步综述了靶向CSVD发病机制中关键环节的干预措施,以期为CSVD的早期诊治提供新思路。Cerebral small vessel disease(CSVD)is a clinical condition resulting from lesions in the small blood vessels within the brain.Cause and mechanism of CSVD are intricate,and early diagnosis and specific treatment are currently lacking in clinical practice.This paper presents a synthesis of recent methodologies for creating animal models of CSVD,as well as a compilation of imaging and biological markers for CSVD early diagnosis.Additionally,the article reviews intervention strategies that target crucial pathways in the development of CSVD,aiming to offer novel insights into early diagnosis and intervention techniques for CSVD.

关 键 词：脑小血管病 动物模型 生物标志物 治疗策略 

分 类 号：R743[医药卫生—神经病学与精神病学]