In situ self-assembly of amphiphilic dextran micelles and superparamagnetic iron oxide nanoparticle-loading as magnetic resonance imaging contrast agents  

作　　者：Linrui Jiang Rong Zheng Ni Zeng Changqiang Wu Hongying Su 

机构地区：[1]Faculty of Chemical Engineering,Kunming University of Science and Technology,Kunming 650500,China [2]Sichuan Key Laboratory of Medical Imaging,North Sichuan Medical College,Nanchong 637000,China

出　　处：《Regenerative Biomaterials》2023年第1期194-204,共11页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China[51963013];Fund of Sichuan Key Laboratory of Medical Imaging(North Sichuan Medical College)[SKLMI201902];Yunnan Ten Thousand Talents Plan Young&Elite Talents Project[YNWR-QNBJ-2019-085].

摘　　要：Polymeric micelles have long been considered as promising nanocarrier for hydrophobic drugs and imaging probes,due to their nanoscale particle size,biocompatibility and ability to loading reasonable amount of cargoes.Herein,a facile method for dextran micelles preparation was developed and their performance as carriers of superparamagnetic iron oxide(SPIO)nanocrystals was evaluated.Amphiphilic dextran(Dex-g-OA)was synthesized via the Schiff base reactions between oxidized dextran and oleylamine,and self-assembled in situ into nano-size micelles in the reaction systems.The self-assembling behaviors of the amphiphilic dextran were identified using fluorescence resonance energy transfer technique by detection the energy transfer signal between the fluorophore pairs,Cy5 and Cy5.5.Hydrophobic SPIO nanoparticles(Fe_(3)O_(4)NPs)were successfully loaded into the dextran micelles via the in situ self-assembly process,leading to a series of Fe_(3)O_(4)NPs-loaded micelle nanocomposites(Fe_(3)O_(4)@Dex-g-OA)with good biocompatibility,superparamagnetism and strongly enhanced T_(2)relaxivity.At the magnetic field of 0.5 T,the Fe_(3)O_(4)@Dex-g-OA nanocomposite with particle size of 116.2±53.7 nm presented a higher T_(2)relaxivity of 327.9 mM_(re)^(-1)·s^(-1)·s^(−1).The prepared magnetic nanocomposites hold the promise to be used as contrast agents in magnetic resonance imaging.

关 键 词：MICELLE DEXTRAN superparamagnetic iron oxide magnetic resonance imaging Schiff base 

分 类 号：R318[医药卫生—生物医学工程]