Polydopamine nanoparticle-mediated mild photothermal therapy for inhibiting atherosclerotic plaque progression by regulating lipid metabolism of foam cells  

作　　者：Shuangshuang Tu Wenzhi Ren Jinru Han Haijing Cui Ting Dai Haoxuan Lu Yanqing Xie Wenming He Aiguo Wu 

机构地区：[1]Department of Cardiology,The First Affiliated Hospital of Ningbo University,Ningbo,Zhejiang Province 315020,China [2]Cixi Institute of Biomedical Engineering,International Cooperation Base of Biomedical Materials Technology and Application,Chinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices&Zhejiang Engineering Research Center for Biomedical Materials,Ningbo Institute of Materials Technology and Engineering CAS,Ningbo 315201,China [3]Advanced Energy Science and Technology Guangdong Laboratory,Huizhou 516000,China [4]University of Chinese Academy of Sciences,Beijing 101408,China

出　　处：《Regenerative Biomaterials》2023年第1期830-838,共9页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China(32171359,31971292,32025021 and 32111540257);the General Research Program of Zhejiang Provincial Department of Health(WKJ-ZJ-2137);the Zhejiang Province Financial Supporting(2020C03110 and 2023C04017);the Key Scientific and Technological Special Project of Ningbo City(2020Z094);the Natural Science Foundation of Ningbo(202003N4001,2021J240 and 20221JCGY010661).

摘　　要：Since apoptosis of foam,cells can induce plaque instability,reducing intracellular lipid content while protecting foam cells from apoptosis is beneficial for the safe and efficient therapy of atherosclerosis.In this study,osteopontin-coupled polydopamine(PDA-OPN)nanoparticles were synthesized and applied to target mild photothermal therapy(PTT)of atherosclerosis.The results from laser confocal microscopy indicate that PDA-OPN nanoparticles can be specially recognized and absorbed by foam cells.Under near-infrared laser irradiation,the mild photothermal generated by PDA-OPN decreases intracellular lipid accumulation but does not induce cell apoptosis.In vivo treatments demonstrate that mild PTT can substantially reduce plaque area and improve plaque stability by upregulating the expression of plaque fibrosis in ApoE^(−/−)mice.Our findings reinforce that the PDA-OPN nanoparticle-mediated mild PTT can inhibit atherosclerotic progression,which provides new insights for developing safe and effective treatment methods for atherosclerosis.

关 键 词：polydopamine nanoparticles photothermal therapy ATHEROSCLEROSIS lipid metabolism 

分 类 号：R318[医药卫生—生物医学工程]