Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications  

作　　者：Dan Zhao Yan Rong Dong Li Chaoliang He Xuesi Chen 

机构地区：[1]CAS Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]College of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China

出　　处：《Regenerative Biomaterials》2023年第1期933-956,共24页再生生物材料（英文版）

基　　金：support from the National Key Research and Development Program of China(2022YFC2604003);National Natural Science Foundation of China(projects 52173147,51973218,52203202,51833010);the Scientific and Technological Development Projects of Jilin Province(20210204136YY).

摘　　要：Stimuli-responsive synthetic polypeptide-containing block copolymers have received considerable attention in recent years.Especially,unique thermo-induced sol-gel phase transitions were observed for elaborately-designed amphiphilic diblock copolypeptides and a range of poly(ethylene glycol)(PEG)-polypeptide block copolymers.The thermo-induced gelation mechanisms involve the evolution of secondary conformation,enhanced intramolecular interactions,as well as reduced hydration and increased chain entanglement of PEG blocks.The physical parameters,including polymer concentrations,sol-gel transition temperatures and storage moduli,were investigated.The polypeptide hydrogels exhibited good biocompatibility in vitro and in vivo,and displayed biodegradation periods ranging from 1 to 5 weeks.The unique thermo-induced sol-gel phase transitions offer the feasibility of minimal-invasive injection of the precursor aqueous solutions into body,followed by in situ hydrogel formation driven by physiological temperature.These advantages make polypeptide hydrogels interesting candidates for diverse biomedical applications,especially as injectable scaffolds for 3D cell culture and tissue regeneration as well as depots for local drug delivery.This review focuses on recent advances in the design and preparation of injectable,thermo-induced physically crosslinked polypeptide hydrogels.The influence of composition,secondary structure and chirality of polypeptide segments on the physical properties and biodegradation of the hydrogels are emphasized.Moreover,the studies on biomedical applications of the hydrogels are intensively discussed.Finally,the major challenges in the further development of polypeptide hydrogels for practical applications are proposed.

关 键 词：injectable hydrogels POLYPEPTIDES stimuli responsive secondary conformation tissue engineering immunotherapy 

分 类 号：TQ427.26[化学工程]