An extracellular matrix-mimetic coating with dual bionics for cardiovascular stents  

作　　者：Nuoya Chen Mingyu Li Haoshaung Wu Yumei Qin Jian Wang Kai Xu Rifang Luo Li Yang Yunbing Wang Xingdong Zhang 

机构地区：[1]National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China [2]Shanxi Key Laboratory of Functional Proteins,Shanxi Jinbo Bio-Pharmaceutical Co.,Ltd,Taiyuan 030032,Shanxi,China [3]Department of Cardiology,General Hospital of Northern Theater Command,Shenyang 110000,China

出　　处：《Regenerative Biomaterials》2023年第1期1149-1160,共12页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China(32101107);CAMS Innovation Fund for Medical Sciences(2021-I2M-5-013).

摘　　要：Anti-inflammation and anti-coagulation are the primary requirements for cardiovascular stents and also the widely accepted trajectory for multi-functional modification.In this work,we proposed an extracellular matrix(ECM)-mimetic coating for cardiovascular stents with the amplified functionalization of recombinant humanized collagen type III(rhCOL III),where the biomimetics were driven by structure mimicry and component/function mimicry.Briefly,the structure-mimic was constructed by the formation of a nanofiber(NF)structure via the polymerization of polysiloxane with a further introduction of amine groups as the nanofibrous layer.The fiber network could function as a three-dimensional reservoir to support the amplified immobilization of rhCoL III.The rhCOL III was tailored for anti-coagulant,anti-inflammatory and endothelialization promotion properties,which endows the ECM-mimetic coating with desired surface functionalities.Stent implantation in the abdominal aorta of rabbits was conducted to validate the in vivo re-endothelialization of the ECM-mimetic coating.The mild inflammatory responses,anti-thrombotic property,promotion of endothelialization and suppression of excessive neointimal hyperplasia confirmed that the ECM-mimetic coating provided a promising approach for the modification of vascular implants.

关 键 词：cardiovascular stent recombinant humanized collagen type III extracellular matrix ANTI-COAGULATION ENDOTHELIALIZATION 

分 类 号：R318[医药卫生—生物医学工程]