血清sPLA2-X、Copeptin水平对老年重症支气管扩张合并感染患者疗效的预测作用  

Prognostic Effect of Serum sPLA2-X And Copeptin Levels in Elderly Patients with Severe Bronchiectasis Combined with Infection

作　　者：邢秋棠 林清荣 张凤芸 Xing Qiutang;Lin Qingrong;Zhang Fengyun(Department of Respiratory and Critical care Medicine,Zhangdian District pede's Hospital,Zibo city,Zibo Shandong 255000,China)

机构地区：[1]淄博市张店区人民医院呼吸与危重症医学科,山东淄博255000

出　　处：《生命科学仪器》2024年第3期84-86,90,共4页Life Science Instruments

基　　金：淄博市医药卫生科研项目:20230302013。

摘　　要：目的探讨分析血清分泌型磷脂酶A2-X(sPLA2-X)与和肽素(Copeptin)水平对老年重症支气管扩张合并感染患者临床治疗效果的预测作用。方法选取2022年1月至2023年12月淄博市张店区人民医院收治的重症支气管扩张合并感染患者132例,检测血清sPLA2-X、Copeptin水平。使用临床肺部感染评分(CPIS)进行病情严重程度评价,分析血清sPLA2-X、Copeptin水平与CPIS评分的相关性。患者入院后,均给予对症治疗,根据治疗效果分为治疗有效组和无效组。分析血清sPLA2-X、Copeptin水平对老年重症支气管扩张合并感染患者疗效的预测价值。结果Pearson相关性分析结果显示,血清sPLA2-X、Copeptin水平与CPIS评分均呈正相关,P<0.05。治疗有效组患者血清sPLA2-X、Copeptin水平均高于无效组,P<0.05;经受试者工作特征曲线(ROC)显示,sPLA2-X预测治疗有效的曲线面积(AUC)为0.838,Copeptin的AUC为0.807,二者联合的AUC为0.904,高于sPLA2-X、Copeptin单独预测,P<0.05。结论老年重症支气管扩张合并感染患者的血清sPLA2-X、Copeptin水平与感染程度密切相关,在疗效预测中具有较高应用价值,可考虑用于该病患者的诊疗和预后判断。Objective:To explore and analyze the predictive effect of serum secreted phospholipase A2-X(sPLA2-X)and Copeptin on the clinical treatment effect of elderly patients with severe bronchiectasis complicated with infection.Methods:From January 2022 to December 2023,132 patients with severe bronchiectasis complicated with infection in Zhangdian District People's Hospital of Zibo were selected,and the serum sPLA2-X and Copeptin levels were detected.Clinical pulmonary infection score(CPIS)was used to evaluate the severity of the disease,and the correlation between serum sPLA2-X and Copeptin levels and CPIS score was analyzed.All patients were given symptomatic treatment after admission,and were divided into effective group and ineffective group according to the therapeutic effect.To analyze the predictive value of serum sPLA2-X and Copeptin levels on the curative effect of elderly patients with severe bronchiectasis complicated with infection.Results:Pearson correlation analysis showed that the serum levels of sPLA2-X and Copeptin were positively correlated with the CPIS score,P<0.05.The levels of serum sPLA2-X and Copeptin in the effective group were higher than those in the ineffective group,P<0.05.The receiver's operating characteristic curve(ROC)showed that the curve area(AUC)of sPLA2-X for predicting the effective treatment was 0.838,and the AUC of Copeptin was 0.807.The AUC of the combination of sPLA2-X and Copeptin was 0.904,which was higher than that of SPLA2-X and Copeptin alone,P<0.05.Conclusion:The serum levels of sPLA2-X and Copeptin in elderly patients with severe bronchiectasis complicated with infection are closely related to the degree of infection,which has high application value in the prediction of curative effect and can be considered for the diagnosis,treatment and prognosis judgment of this disease.

关 键 词：支气管扩张 肺部感染 分泌型磷脂酶A2-X 和肽素 

分 类 号：R737.33[医药卫生—肿瘤]