疏肝消瘰丸治疗肉芽肿性乳腺炎肿块期肝郁痰凝证的临床研究  

Clinical Observation on Shugan Xiaoluo Pills in the Treatment of Granulomatous Lobular Mastitis in the Mass Stage of Liver Stagnation And Phlegm Coagulation Type

作　　者：焦方敏 胡玉蝶 王晓丽 杨争[1] 胡金辉[1] Fangmin Jiao;Yudie Hu;Xiaoli Wang;Zheng Yang;Jinhui Hu(The First Hospital of Hunan University of Chinese Medicine,Changsha Hunan 410021,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410021

出　　处：《生命科学仪器》2024年第3期87-90,共4页Life Science Instruments

基　　金：湖南省教育厅重点课题(23A0295);湖南省自然科学基因科卫联合项目(2023JJ60346);湖南省自然科学基金面上项目(2023JJ30470);湖南省卫计委一般指导性课题(D202304139639);第五批全国中医临床优秀人才湘中医药科教便函[2022]2号;湖南省中医药管理局重点课题(C2022020)。

摘　　要：目的研究分析疏肝消瘰丸治疗肉芽肿性乳腺炎(GLM)肿块期肝郁痰凝证的临床效果。方法选取2021年12月至2022年12月湖南中医药大学第一附属医院收治的60例GLM肿块期肝郁痰凝证患者,采用简单随机法分为对照组与观察组,各30例。两种均给予常规治疗,对照组加用甲泼尼龙,观察组加用疏肝消瘰丸。治疗12周后,对比两组临床疗效、临床证候积分、疼痛程度、肿块大小及不良反应发生情况。结果治疗后,两组临床证候积分较治疗前显著降低,且观察组临床证候积分较对照组更低,P<0.05;两组VAS评分均较治疗前显著降低,P<0.01,但治疗后两组间VAS评分对比,P>0.05;两组体表肿块直径均较治疗前缩小,且与对照组相比,观察组肿块直径缩小更显著,P<0.01。治疗12周后,观察组总有效率高于对照组,P<0.05。两组不良反应对比,P>0.05。结论对GLM肿块期肝郁痰凝证患者采用疏肝消瘰丸治疗效果显著,可改善患者临床症状,缩小肿块,减轻疼痛,且不增加不良反应。Objective:To study and analyze the clinical effect of Shugan Xiaolou Pill in treating granulomatous mastitis(GLM)with liver depression and phlegm coagulation syndrome in the mass stage.Methods:From December 2021 to December 2022,60 patients with liver depression and phlegm coagulation syndrome in GLM mass stage were selected and randomly divided into control group and observation group with 30 cases in each group.Both groups were given routine treatment,the control group was given methylprednisolone,and the observation group was given Shugan Xiaoyu Pill.After 12 weeks of treatment,the clinical efficacy、clinical syndrome score、pain degree、mass size and adverse reactions of the two groups were compared.Results:After treatment,the clinical syndrome score of the two groups was significantly lower than that before treatment,and the clinical syndrome score of the observation group was lower than that of the control group,P<0.05;The VAS scores of the two groups were significantly lower than before treatment,P<0.05,but after treatment,the VAS scores of the two groups were compared,P>0.05;The diameter of the body surface mass in both groups was smaller than that before treatment,and the diameter of the mass in the observation group was more significant than that in the control group,P<0.05.After 12 weeks of treatment,the total effective rate of the observation group was higher than that of the control group,P<0.05.The adverse reactions of the two groups were compared,P>0.05.Conclusion:Shugan Xiaoluo Pill is effective in treating GLM patients with stagnation of liver-qi and phlegm-coagulation,which can improve the clinical symptoms,reduce the mass and relieve the pain without increasing adverse reactions.

关 键 词：肉芽肿性乳腺炎 肿块期 肝郁痰凝证 疏肝消瘰丸 

分 类 号：R737.9[医药卫生—肿瘤]