育龄女性甲状腺癌患者甲状腺激素与血脂水平的相关性研究  

Study on the correlation between thyroid hormones and blood lipid levels in women of childbearing age with thyroid cancer

作　　者：莫婷燕 崔静[2] 邵长香 虞晨 付锦艳 俞菁 MO Tingyan;CUI Jing;SHAO Changxiang;YU Chen;FU Jinyan;YU Jing(Department of Nutrition,Shanghai Changning Maternity and Infant Health Hospital/Maternity and Infant Health Hospital Affiliated to East Normal University,Shanghai 200051,China;Department of Breast Surgery,Shanghai Changning Maternity and Infant Health Hospital/Maternity and Infant Health Hospital Affiliated to East Normal University,Shanghai 200051,China;Department of Obstetrics,Shanghai Changning Maternity and Infant Health Hospital/Maternity and Infant Health Hospital Affiliated to East Normal University,Shanghai 200051,China;Department of Physical Examination,Shanghai Changning Maternity and Infant Health Hospital/Maternity and Infant Health Hospital Affiliated to East Normal University,Shanghai 200051,China)

机构地区：[1]上海市长宁区妇幼保健院/华东师范大学附属妇幼保健院营养科,上海200051 [2]上海市长宁区妇幼保健院/华东师范大学附属妇幼保健院乳腺科,上海200051 [3]上海市长宁区妇幼保健院/华东师范大学附属妇幼保健院产科,上海200051 [4]上海市长宁区妇幼保健院/华东师范大学附属妇幼保健院体检科,上海200051

出　　处：《癌症进展》2024年第14期1573-1576,1588,共5页Oncology Progress

基　　金：上海市卫生健康委员会科研项目(202140015);上海市长宁区卫生健康委员会科研课题(20194Y017)。

摘　　要：目的探讨育龄女性甲状腺癌患者甲状腺激素与血脂水平的相关性。方法选取128例育龄女性甲状腺癌患者和128例健康育龄女性,分别作为研究组和对照组。比较两组受试者的临床特征,采用Pearson相关分析法分析育龄女性甲状腺癌患者甲状腺激素与血脂水平的相关性。绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),分析甲状腺激素水平对育龄女性甲状腺癌患者高脂血症的预测价值。结果研究组患者促甲状腺素(TSH)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均明显高于对照组,游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、高密度脂蛋白胆固醇(HDL-C)水平均明显低于对照组,差异均有统计学意义(P﹤0.01)。Pearson相关分析结果显示,育龄女性甲状腺癌患者TSH水平与TC、TG、LDL-C水平均呈正相关(P﹤0.01),与HDL-C水平呈负相关(P﹤0.01);FT_(3)、FT_(4)水平与TC、TG、LDL-C水平均呈负相关(P﹤0.01),与HDL-C水平均呈正相关(P﹤0.01)。128例育龄女性甲状腺癌患者中,74例发生高脂血症,发生率为57.81%。ROC曲线显示,TSH、FT_(3)、FT_(4)联合检测预测育龄女性甲状腺癌患者高脂血症的AUC为0.933,灵敏度、特异度、约登指数分别为0.969、0.867、0.836,均高于各指标单独检测。结论育龄女性甲状腺癌患者甲状腺激素与血脂水平有关,TSH水平升高及FT_(3)、FT_(4)水平降低会增加高脂血症的发生风险,临床应积极对症干预,以纠正血脂异常,预防高脂血症发生。Objective To investigate the correlation between thyroid hormones and blood lipid levels in women of childbearing age with thyroid cancer.Method A total of 128 women of childbearing age with thyroid cancer and 128 healthy women of childbearing age were selected as study group and control group,respectively.The clinical characteristics of the two groups were compared,and Pearson correlation analysis was used to analyze the correlation between thyroid hormones and blood lipid levels in women of childbearing age with thyroid cancer.The receiver operating characteristic(ROC)curve was plotted,and the area under the curve(AUC)was calculated to analyze the predictive value of thyroid hormone levels for hyperlipidemia in women of childbearing age with thyroid cancer.Result The levels of thyroidstimulating hormone(TSH),total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)in the study group were significantly higher than those in the control group,while the levels of free triiodothyronine(FT_(3)),free thyroxine(FT_(4))and high-density lipoprotein cholesterol(HDL-C)in the study group were significantly lower than those in the control group,and the differences were statistically significant(P<0.01).The results of Pearson correlation analysis showed that the TSH level in women of childbearing age with thyroid cancer was positively correlated with TC,TG and LDL-C levels(P<0.01),and negatively correlated with HDL-C level(P<0.01);the FT_(3)and FT_(4)levels were negatively correlated with TC,TG and LDL-C levels(P<0.01),and positively correlated with HDL-C level(P<0.01).Among 128 women of childbearing age with thyroid cancer,74(57.81%)had hyperlipidemia.ROC curve showed that the AUC of TSH,FT_(3)and FT_(4)combined detection in predicting hyperlipidemic in women of childbearing age with thyroid cancer was 0.933,and the sensitivity,specificity and Youden index were 0.969,0.867 and 0.836,respectively,which were higher than each index single detection.Conclusion Thyroid hormones are related to blood lipi

关 键 词：甲状腺癌 育龄女性 甲状腺激素 血脂 相关性 

分 类 号：R736.1[医药卫生—肿瘤]