支撑喉镜下低温等离子射频消融术与传统喉裂开术治疗早期声门型喉癌的疗效比较  

Comparison of the efficacy of low-temperature plasma radiofrequency ablation under self-retaining laryngoscope and traditional laryngofissure in the treatment of early glottic carcinoma

作　　者：邢金燕 谭建成 刘鑫国 XING Jinyan;TAN Jiancheng;LIU Xinguo(Department of Otorhinolaryngology,Zhumadian Central Hospital,Zhumadian 463000,He’nan,China)

机构地区：[1]驻马店市中心医院耳鼻咽喉科,河南驻马店463000

出　　处：《癌症进展》2024年第14期1601-1604,共4页Oncology Progress

摘　　要：目的比较支撑喉镜下低温等离子射频消融术(LPRFA)与传统喉裂开术治疗早期声门型喉癌(GC)的疗效。方法根据手术方法的不同将66例早期GC患者分为对照组(n=33,传统喉裂开术)和观察组(n=33,支撑喉镜下LPRFA)。比较两组患者的手术相关指标、疼痛程度[视觉模拟评分法(VAS)]、临床疗效、术后并发症发生情况、生活质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)]及复发情况。结果观察组患者的手术时间和住院时间均明显短于对照组,术中出血量明显少于对照组,差异均有统计学意义(P﹤0.01)。术后1、3天,观察组患者VAS评分均明显低于对照组,差异均有统计学意义(P﹤0.01)。观察组患者的总有效率高于对照组,术后并发症总发生率低于对照组,差异均有统计学意义(P﹤0.05)。术后3、6个月,两组患者EORTC QLQ-C30评分均高于本组术前,观察组患者EORTC QLQ-C30评分均高于对照组,差异均有统计学意义(P﹤0.05)。术后6个月,两组患者复发率比较,差异无统计学意义(P﹥0.05)。结论支撑喉镜下LPRFA治疗早期GC患者的临床疗效较好,可加快患者术后恢复,减轻术后疼痛,降低术后并发症发生率,提高生活质量。Objective To compare the efficacy of low-temperature plasma radiofrequency ablation(LPRFA)under self-retaining laryngoscope and traditional laryngofissure in the treatment of early glottic carcinoma(GC).Method According to different surgical methods,66 patients with early GC were divided into control group(n=33,received traditional laryngofissure)and observation group(n=33,received LPRFA under self-retaining laryngoscope).The surgical indicators,pain degree[visual analogue scale(VAS)],clinical efficacy,postoperative complications,quality of life[European Organization for Research and Treatment of Cancer quality of life questionnaire core 30(EORTC QLQ-C30)]and recurrence were compared between the two groups.Result The operation time and hospital stay in the observation group were significantly shorter than those in the control group,and the amount of intraoperative blood loss was significantly less than that in the control group,and the differences were statistically significant(P<0.01).One and three days after surgery,the VAS scores in observation group were significantly lower than those in control group,and the differences were statistically significant(P<0.01).The total effective rate of the observation group was higher than that of the control group,and the total incidence of postoperative complications was lower than that of the control group,and the differences were statistically significant(P<0.05).At 3 and 6 months after surgery,the EORTC QLQ-C30 scores in both groups were higher than those before surgery,and the EORTC QLQ-C30 scores in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).At 6 months after surgery,there was no significant difference in the recurrence rate between the two groups(P>0.05).Conclusion The clinical efficacy of LPRFA under selfretaining laryngoscope in the treatment of early GC patients is good,which can accelerate the postoperative recovery of patients,reduce postoperative pain,reduce the incidence of postoperative

关 键 词：早期声门型喉癌 传统喉裂开术 支撑喉镜下低温等离子射频消融术 疗效 术后并发症 

分 类 号：R739.65[医药卫生—肿瘤]