慢加亚急性肝衰竭的发病机制研究进展  

Research Progress of Pathogenesis of Acute-on-Chronic Liver Failure

作　　者：谢芳[1,2] 郑文凯 李聪 李平 谭善忠 XIE Fang;ZHENG Wenkai;LI Cong;LI Ping;TAN Shanzhong(Department of Integrated TCM and Western Medicine,Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210003,China;Department of Liver Diseases,Eastern Theater Command General Hospital,Nanjing 210002,China)

机构地区：[1]南京中医药大学附属南京医院中西医结合科,南京210003 [2]东部战区总医院肝病科,南京210002

出　　处：《医学综述》2024年第19期2338-2343,共6页Medical Recapitulate

基　　金：江苏省中医药领军人才培养项目(SLJ0216);东部战区总医院科技创新研究计划项目(2023JCYJZD078)。

摘　　要：肝衰竭是由多种因素引起的严重肝损伤,其死亡率高,对人类生命和健康带来严重影响。肝衰竭发病机制复杂,近年来其一直是肝脏疾病领域的研究热点。肝衰竭存在复杂的免疫和炎症反应过程。其中,固有免疫和适应性免疫均与肝衰竭的发病机制密切相关,而各种免疫细胞和炎症细胞因子在其发病机制中发挥了重要作用。因此,研究肝衰竭的发病机制对于研发新药、控制患者病情进展、降低患者死亡率、提高临床诊疗水平具有重要意义。Liver failure is a serious liver injury caused by many factors,which has a high mortality rate and has a serious impact on human life and health.The pathogenesis of liver failure is complex,and its research has been a hot topic in the field of liver diseases in recent years.There are complex immune and inflammatory processes in liver failure.Among them,both innate immunity and adaptive immunity are closely related to the pathogenesis of liver failure,and various immune cells and inflammatory cytokines play important roles in its pathogenesis.Therefore,studying the pathogenesis of liver failure is of great significance for developing new drugs,controlling disease progression,reducing patient mortality,and improving the clinical diagnosis and treatment levels.

关 键 词：慢加亚急性肝衰竭 免疫 炎症反应 

分 类 号：R575.3[医药卫生—消化系统]