基于脑肠轴探讨抗抑郁药物对消化系统疾病的治疗策略  

Exploring antidepressant-based therapeutic strategy for digestive disorders based on brain-gut axis

作　　者：李熳[1] Man Li(The Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院,天津市300211

出　　处：《世界华人消化杂志》2024年第8期556-560,共5页World Chinese Journal of Digestology

基　　金：天津市卫生健康委员会科技项目,No.TJWJ2021MS017.

摘　　要：在临床上精神心理障碍与消化系统疾病的共病愈发常见,二者既存在共同的发病机制,同时也互为因果,其中当以抑郁症研究最为广泛.脑肠轴是中枢神经系统和肠神经系统之间双向信息交流通路,该通路的提出解释了许多消化系统疾病与精神心理障碍共病的原因,同时也为消化系统疾病的诊治提供了新的可能.其中,一些研究已经证实了抗抑郁药物在改善消化系统疾病症状方面的治疗潜力.Co-morbidity between psychiatric disorders and digestive disorders is becoming more and more common in clinical practice.They have common pathogenesis as well as mutual causation,among which depression is the most widely studied.The brain-gut axis is a bi-directional information exchange pathway between the central nervous system and the enteric nervous system,which has been proposed to explain the mechanisms of co-morbidity between many digestive disorders and psychosomatic disorders.Meanwhile,it also provides new possibilities for the diagnosis and treatment of digestive disorders.Several studies have demonstrated the therapeutic potential of antidepressants in improving the symptoms of digestive disorders.

关 键 词：抗抑郁药 神经调节剂 功能性胃肠病 脑肠轴 

分 类 号：R57[医药卫生—消化系统]