不同致聋基因突变的人工耳蜗植入术后患儿皮层诱发电位的研究  

Evoked Cortical Potential in Children with Different Deaf-Inducing Gene Mutations After Cochlear Implantation

作　　者：王漾[1] 朱晓丹[1] 齐景翠[1] 张园[1] 叶放蕾[1] WANG Yang;ZHU Xiaodan;QI Jingcui;ZHANG Yuan;YE Fanglei(Department of Otology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院耳科,河南郑州450000

出　　处：《河南医学研究》2024年第17期3085-3088,共4页Henan Medical Research

基　　金：河南省医学教育研究项目(Wjlx2022056)。

摘　　要：目的观察不同致聋基因突变的人工耳蜗植入患儿皮层诱发电位(CAEP)的差异。方法分析郑州大学第一附属医院耳科32例行单侧人工耳蜗植入术(植入型号为澳大利亚CI512)的无残存听力,且SLC26A4基因、GJB2基因或TMPRSS3基因突变患儿的临床资料,分为A、B、C组。于术后1个月/ba1/和/ba4/声刺激下分别行CAEP检测,记录/ba1/和/ba4/声刺激下P1波引出率、潜伏期、振幅。结果/ba1/和/ba4/声刺激下,A、B组引出率差异无统计学意义(P>0.05);A、B组引出率均高于C组,差异有统计学意义(P<0.05)。/ba1/和/ba4/声刺激下,A、B组潜伏期差异无统计学意义(P>0.05);A、B组潜伏期短于C组,差异有统计学意义(P<0.05)。/ba1/和/ba4/声刺激下,A、B、C组振幅比较,差异无统计学意义(P>0.05)。结论SLC26A4基因、GJB2基因突变的CAEP的P1波引出率高于TMPRSS3基因突变,且LC26A4基因、GJB2基因突变的CAEP的P1波潜伏期短于TMPRSS3基因突变。Objective To observe the difference of evoked cortical potential(CAEP)in children with cochlear implant with different deaf-inducing gene mutations.Methods The clinical data of 32 children with no residual hearing and SLC26A4 gene,GJB2 gene or TMPRSS3 gene mutation who underwent unilateral cochlear implantation(CI512)in the Department of Otology of the First Affiliated Hospital of Zhengzhou University were analyzed and divided into A,B and C groups.CAEP detection was performed under/ba1/and/ba4/acoustic stimulation one month after surgery,respectively,and P1 wave extraction rate,latency and amplitude were recorded under/ba1/and/ba4/acoustic stimulation.Results There was no significant difference in extraction rate between groups A and B under acoustic stimulation of/ba1/and/ba4/(P>0.05).The extraction rate of groups A and B was higher than that of group C,and the difference was statistically significant(P<0.05).There was no significant difference in latency between groups A and B under acoustic stimulation(P>0.05).The incubation period of groups A and B was shorter than that of group C(P<0.05).There was no significant difference in amplitudes between groups A,B and C under acoustic stimulation(P>0.05).Conclusion The P1 wave extraction rate of CAEP with SLC26A4 gene and GJB2 gene mutation is higher than that of TMPRSS3 gene mutation,and the P1 wave latency of CAEP with LC26A4 gene and GJB2 gene mutation is shorter than that of TMPRSS3 gene mutation.

关 键 词：皮层诱发电位 耳聋 基因突变 人工耳蜗植入 

分 类 号：R764[医药卫生—耳鼻咽喉科]