血清PDCD5、CYFRA21-1与腹腔镜胃癌根治术后预后不良的相关性  

Correlation Between Serum PDCD5,CYFRA21-1 and Poor Prognosis After Laparoscopic Radical Gastrectomy for Gastric Cancer

作　　者：任乐华 REN Lehua(Department of Tumor Surgery,Tumor Hospital Xinyang,Xinyang 464000,China)

机构地区：[1]信阳市肿瘤医院肿瘤外科,河南信阳464000

出　　处：《河南医学研究》2024年第17期3154-3158,共5页Henan Medical Research

摘　　要：目的探析血清程序性细胞凋亡因子5(PDCD5)、细胞角蛋白19片段抗原21-1(CYFRA21-1)与腹腔镜胃癌根治术后预后不良之间的相关性。方法回顾性分析,收集信阳市肿瘤医院2020年1月至2021年1月接受腹腔镜胃癌根治术治疗的95例胃癌患者资料,将术后3 a内复发患者纳入预后不良组(31例),未复发患者纳入预后良好组(64例),比较不同预后患者基线资料和根治术前血清PDCD5、CYFRA21-1水平,分析血清PDCD5、CYFRA21-1与胃癌患者腹腔镜胃癌根治术后预后不良的关系。结果预后不良组术前血清PDCD5、胃泌素(G-17)水平低于预后良好组,血清CYFRA21-1、胚胎抗原(CEA)、甲胎蛋白(AFP)水平高于预后良好组(P<0.05)。经Cox生存分析结果显示,胃癌患者预后不良可能与入院时血清PDCD5、G-17、CYFRA21-1、CEA、AFP水平异常有关(P<0.05)。血清PDCD5、CYFRA21-1对胃癌患者不良预后的发生存在负向交互作用,血清PDCD5低水平且CYFRA21-1高水平时不良预后发生风险是血清PDCD5高水平且CYFRA21-1低水平的103.714倍。结论腹腔镜胃癌根治术患者术后预后不良风险可能与术前血清PDCD5低水平、CYFRA21-1高水平异常有关,应引起临床重视。Objective To explore the correlation between serum programmed cell apoptosis factor 5(PDCD5),cytokeratin 19 fragment antigen 21-1(CYFRA21-1)and poor prognosis after laparoscopic radical gastrectomy.Methods A retrospective analysis was conducted to collect data from 95 gastric cancer patients who underwent concurrent laparoscopic radical gastrectomy at Tumor Hospital Xinyang from January 2020 to January 2021.The patients with recurrence within 3 years after operation were included in the poor prognosis group(31 cases),and the patients without recurrence were included in the good prognosis group(64 cases).The baseline data of patients with different prognosis and the levels of serum PDCD5 and CYFRA21-1 before radical operation were compared,and the relationship between serum PDCD5 and CYFRA21-1 and the poor prognosis of patients with gastric cancer after laparoscopic radical gastrectomy was analyzed.Results The preoperative serum levels of PDCD5 and gastrin-17(G-17)in the poor prognosis group were lower than those in the good prognosis group,while the serum levels of CYFRA21-1,carcinoembryonic antigen(CEA)and alpha-fetoprotein(AFP)were higher than those in the good prognosis group(P<0.05).The results of Cox survival regression analysis showed that poor prognosis in gastric cancer patients may be related to abnormal levels of serum PDCD5,G-17,CYFRA21-1,CEA and AFP at admission(P<0.05).There was a negative interaction between serum PDCD5 and CYFRA21-1 on the occurrence of poor prognosis in patients with gastric cancer.The risk of poor prognosis when serum PDCD5 was low and CYFRA21-1 was high was 103.714 times that of serum PDCD5 was high and CYFRA21-1 was low.Conclusion The risk of poor prognosis in patients undergoing laparoscopic radical gastrectomy may be related to the abnormal levels of preoperative serum PDCD5 and CYFRA21-1,which should be paid attention to in clinical practice.

关 键 词：胃癌 腹腔镜根治术 程序性细胞凋亡因子 细胞角蛋白19片段抗原21-1 复发 

分 类 号：R735.2[医药卫生—肿瘤]