滋肾益智方对脑梗死后轻度认知障碍患者脑血流灌注及认知功能的影响  

Effect of Zishen Yizhi Formula on Cerebral Blood Flow Perfusion and Cognitive Function in Patients with Mild Cognitive Impairment After Cerebral Infarction

作　　者：李栋 LI Dong(Department of Internal Medicine,Ruzhou Hospital of Traditional Chinese Medicine,Pingdingshan 467599,China)

机构地区：[1]汝州市中医院内科,河南平顶山467599

出　　处：《河南医学研究》2024年第17期3228-3231,共4页Henan Medical Research

摘　　要：目的探讨滋肾益智方对脑梗死后轻度认知障碍(MCI)患者脑血流灌注及认知功能的影响。方法选取2021年8月至2022年8月汝州市中医院收治的80例脑梗死后MCI患者,按随机数字表法随机分配为两组,每组各包含40例患者。两组均接受对症治疗,在此基础上,给予对照组奥拉西坦治疗,给予观察组奥拉西坦+滋肾益智方治疗,治疗2个月。比较两组疗效、脑血流灌注指标[大脑中动脉(MCA)和大脑前动脉(ACA)的搏动指数和平均血流速度],采用简易智力状态量表(MMSE)和蒙特利尔认知评估量表(MoCA)评估患者认知功能,采用改良Barthel指数(MBI)评估患者的日常生活功能,最后评价两组用药期间的安全性。结果观察组治疗总有效率较对照组高(P<0.05)。治疗结束后,两组ACA和MCA的平均血流速度均有所提升,其中观察组的平均血流速度提升更明显(P<0.05),而两组ACA和MCA的搏动指数比较,差异无统计学意义(P>0.05)。治疗结束后,两组MMSE、MoCA、MBI评分均有所提升,其中观察组的评分提升更明显(P<0.05)。比较两组不良反应发生频次,差异无统计学意义(P>0.05)。结论在西药基础上结合滋肾益智方治疗脑梗死后MCI,可有效改善患者脑血流灌注和认知功能,且具有较好的安全性。Objective To study the therapeutic effect of Zishen Yizhi Formula on patients with mild cognitive impairment(MCI)after cerebral infarction,and to analyze the impact of drugs on cerebral blood flow perfusion and cognitive function in patients.Methods A total of 80 patients with MCI after cerebral infarction from August 2021 to August 2022 at the Ruzhou Hospital of Traditional Chinese Medicine were selected.Using a random number table method,the samples were divided into two groups,with 40 patients in each group.All patients received symptomatic treatment for cerebral infarction.The control group was treated with oracetam capsules,while the observation group was treated with a combination of Zishen Yizhi Formula on the basis of the control group.All patients were treated for 2 months.The efficacy,cerebral blood perfusion[mean blood flow velocity and pulse index of anterior cerebral artery(ACA)and middle cerebral artery(MCA)]were compared between the two groups.The cognitive function of patients was evaluated by mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA).The modified Barthel index(MBI)was used to evaluate the daily life function of the patients.The occurrence of adverse reactions during treatment was counted.Results After treatment,compared with control group,the total effective rate of the observation group was higher(P<0.05).After treatment,the average blood flow velocity of ACA and MCA in both groups increased,with the observation group showing a more significant increase in average blood flow velocity(P<0.05).However,there was no statistical difference in the pulsatility index of ACA and MCA in both groups(P>0.05).After treatment,the MMSE,MoCA,and MBI scores of both groups increased,and compared with control group,the observation group was higher(P<0.05).There was no statistical difference in the frequency of adverse reactions between the two groups(P>0.05).Conclusion The combination of Zishen Yizhi Formula and Western medicine treatment can help patients with mild cognitive impai

关 键 词：滋肾益智方 脑梗死 认知障碍 脑血流灌注 认知功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]