LBX2基因高表达与结直肠癌预后的相关性研究  

Correlation between elevated expression of LBX2 gene and prognosis in colorectal cancer

作　　者：钱林辉 王海姣 李晓 刘建刚 QIAN Lin-hui;WANG Hai-jiao;LI Xiao;LIU Jian-gang(Department of Anorectal Surgery,Feicheng People's Hospital,Taian 271600,China;Department of Critical Care Medicine,Feicheng People's Hospital,Taian 271600,China;Department of Gastrointestinal Surgery,the Second Affiliated Hospital of Shandong First Medical University,Taian 271600,China)

机构地区：[1]山东省泰安市肥城市人民医院肛肠外科,山东泰安271600 [2]山东省泰安市肥城市人民医院重症医学科,山东泰安271600 [3]山东第一医科大学第二附属医院胃肠外科,山东泰安271600

出　　处：《中国现代普通外科进展》2024年第8期607-612,共6页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探究LBX2在结直肠癌中的表达水平,揭示LBX2在结直肠癌发展中的潜在作用。方法:通过挖掘TCGA数据库的数据,比较配对结直肠癌组织与正常结直肠组织中LBX2的表达水平以及结直肠癌临床病理特征与LBX2表达的关系,受试者工作特征曲线评价LBX2作为诊断结直肠癌的指标的临床价值。结果:LBX2在结直肠癌组织中的表达明显高于正常组织,高表达患者预后更差。LBX2高表达是独立的结直肠癌预后危险因素,与较短的总生存期(OS)和疾病特异性生存期(DSS)相关。结论:LBX2具有成为结直肠癌预后生物标志物的潜在价值。Objective:To explore the expression level of LBX2 in colorectal cancer and reveal the potential role of LBX2 in colorectal cancer progression.Methods:The present study employed utilized data mining techniques on the Cancer Genome Atlas database to compare the expression level of LBX2 in matched colorectal cancer and normal tissues.Additionally,an investigation was conducted to explore the relationship between clinicopathological features and LBX2 expression.Furthermore,a receiver operating characteristic curve was generated to assess the diagnostic value of LBX2.Results:A statistically significant divergence in patient prognosis was ob-served between those with high and low expression levels.Elevated levels of LBX2 have been identified as a significant independent prognostic indicator for colorectal cancer,correlating with decreased overall survival and disease-specific survival.Conclusion:Patients with high expres-sion of LBX2 exhibit a considerably poor prognosis,thus highlighting its potential as a valuable prognostic biomarker for individuals diagnosed with colorectal cancer.

关 键 词：结直肠肿瘤 LBX2 预后 生物标志物 

分 类 号：R735.3[医药卫生—肿瘤]