儿童急性淋巴细胞白血病及其治疗所伴发的中枢神经系统损伤研究进展  

Research progress of central nervous system injury associated with pediatric acute lymphoblastic leukemia and its treatment

作　　者：褚思嘉(综述) 汤继宏(审校)[1] CHU Sijia;TANG Jihong(Department of Neurology,Children’s Hospital of Soochow University,Suzhou 215025,Jiangsu,China;Department of Child Healthcare,Kunshan Bailu Community Health Service Center,Suzhou 215300,Jiangsu,China)

机构地区：[1]苏州大学附属儿童医院神经内科,江苏苏州215025 [2]昆山市柏庐社区卫生服务中心儿童保健科,江苏苏州215300

出　　处：《临床儿科杂志》2024年第9期811-816,共6页Journal of Clinical Pediatrics

基　　金：苏州市科技计划(医疗卫生科技创新-临床前沿技术)项目(No.SKY2022007)。

摘　　要：急性淋巴细胞白血病是儿童最常见的恶性肿瘤,急性淋巴细胞白血病伴发的中枢神经系统并发症对患儿预后产生了一定影响。除了肿瘤本身可造成脑损伤外,近来国内外研究者发现抗肿瘤治疗也存在一定的损伤作用。通过对急性淋巴细胞白血病患儿治疗后伴发中枢神经系统损伤的探讨,有助于临床医生早期识别、早期干预并发症,使患儿获得更好的预后和生活质量。Acute lymphoblastic leukemia(ALL)is the most common malignancy in children,and its central nervous system complications significantly impact the prognosis of children.In addition to the brain damage caused by ALL itself,recent researches have shown that anti-tumor therapy may also result in adverse effects.Investigating central nervous system injury associated with anti-tumor therapy in children with ALL is crucial for early identification and intervention of complications,ultimately leading to improved prognosis and quality of life for children.

关 键 词：中枢神经系统损伤 急性淋巴细胞白血病 损伤机制 儿童 

分 类 号：R733.71[医药卫生—肿瘤]