Trojan horses in tumor:engineered pyroelectric and photodynamic nanocomposites for NIR-induced cell apoptosis and tumor growth inhibition  

作　　者：Yanxi Yang Xinru Kong Xueli Ren Yandai Lin Zhe Liu 

机构地区：[1]Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin 300072,China [2]Tianjin Key Laboratory of Brain Science and Neural Engineering,Tianjin University,Tianjin 300072,China

出　　处：《Science China Chemistry》2024年第9期3050-3062,共13页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(82072057,82311540023)。

摘　　要：It is desirable but always challenging to develop a cutting-edge tumor treatment strategy with high therapeutic efficacy,lesiontargeted precision and mild accessibility.Compared to traditional treatment modalities,photodynamic therapy has been widely studied since the generation of reactive oxygen species(ROS)at cancerous lesions unprecedentedly offers a convenient approach for localized tumor eliminations.Nevertheless,the consumption of oxygen for ROS production in a hypoxic tumor microenvironment has dramatically limited its feasibility and efficacy.Herein,the engineered nanocomposites of BTO@PDA-ICGHA with photodynamic and pyroelectric performances have been fabricated and applied to the photodynamic-pyroelectric dynamic treatments.The continuing ROS production derived from intracellular oxygen(O_(2))and water(H_(2)O)by laser irradiation contributed to the superb tumor cell apoptosis and significant tumor growth inhibition.Thus,this study has validated a new concept by depositing the engineered nanocomposites at the tumor just like Trojan horses,facilitating ROS release as killers and exerting the NIR-induced cell apoptosis and tumor growth inhibition with high therapeutic efficiency and expectable translational perspectives.

关 键 词：NANOCOMPOSITES pyroelectric effect photodynamic therapy cell apoptosis tumor growth inhibition 

分 类 号：R73-3[医药卫生—肿瘤] TB332[医药卫生—临床医学]