pH-responsive metal nanoparticles as high contrast theranostic agents for selective imaging and synergistic cancer therapy  

作　　者：Sichao Tian Xiaofeng He Xiao Wu Dongxue Hu Qing-Hua Xu 

机构地区：[1]Department of Chemistry,National University of Singapore,Singapore 117543,Singapore [2]National University of Singapore(Suzhou)Research Institute,Suzhou 215123,China [3]Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China [4]Department of Biological Sciences,Faculty of Science,National University of Singapore,Singapore 117558,Singapore

出　　处：《Science China Chemistry》2024年第9期3063-3070,共8页中国科学（化学英文版）

基　　金：supported by the Science and Technology Project of Jiangsu Province(BZ2022056);the Ministry of Education,Singapore(Tier 1 A-8000013-00-00)。

摘　　要：The low signal-to-noise ratio(S/N)and single functionality of fluorescence imaging agents have limited their practical applications.Bright two-photon excitation(2PE)imaging probes are highly desirable in vivo with larger imaging depth,minor autofluorescence background,and less photodamage.Herein,we developed responsive aggregated gold nanoparticles(Au NPs)as high contrast 2PE imaging agents,capable of emitting red fluorescence upon excitation of near-infrared(NIR)laser and possessing a high signal-to-noise ratio(S/N of 2,475).By forming aggregates in situ inside tumor tissue,doxorubicin hydrochloride(DOX)-loaded mix-charged gold nanoparticles(DOX-MC-Au NPs)were utilized to act as selective fluorescence imaging probes and precise therapy agents.These high-contrast theranostic agents offer a promising potential for precise cancer imaging and therapy,which might open a new venue to multifunctional and noninvasive theranostics.

关 键 词：metal nanoparticles two-photon excitation high contrast imaging agents fluorescence imaging cancer therapy 

分 类 号：R730.5[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]