Synthetic fungal melanin UV absorbers  

作　　者：Chao Wang Rong Zhang Jianhua Zhang Xueqian Zhang Hengjie Zhang Huan Cao Zhen Yang Yiwen Li 

机构地区：[1]College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China [2]Department of Radiology,Huaxi MR Research Center,Functional and Molecular Imaging Key Laboratory of Sichuan Province,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Science China Chemistry》2024年第9期3098-3110,共13页中国科学（化学英文版）

基　　金：supported by National Natural Science Foundation of China(52225311);Sichuan Science and Technology Program(2024NSFSC1018);China Postdoctoral Science Foundation(2024M752208);Postdoctoral Fellowship Program of CPSF(GZC20241108);the Fundamental Research Funds for Central Universities。

摘　　要：Agents with robust ultraviolet(UV)absorption capabilities play a vital role in safeguarding organisms and inorganic materials from UV damage.Nonetheless,the synthetic procedures towards these UV absorbers are usually lengthy and complicated,accompanied by undesirable side reactions and the generation of toxic substances.In nature,allomelanin,a class of melanins variant found in melanized fungi near the Chernobyl nuclear power plant,plays crucial roles in the cell wall of melanized fungi,offering resistance to harsh external environments and promising UV resistance capabilities.Notably,allomelanin can be rapidly biosynthesized via the polymerization of 1,8-dihydroxynaphthalene in presence of enzymes in fungi.Inspired by this,we report here a green enzymatic polymerization strategy to efficiently and eco-friendly synthesize polydihydroxynaphthalene(PDHN)-based artificial allomelanin nanoparticles(NPs)with interesting features.Theoretical calculations and experimental results demonstrated that the PDHN NPs exhibited excellent UVabsorption capacity,surpassing another widely used artificial melanin,polydopamine(PDA).Moreover,the light absorption mechanism of PDHN NPs was systematically elucidated for the first time.Then,the PDHN NPs were incorporated with polyvinyl alcohol(PVA)to create an anti-aging composite film with significantly enhanced UV shielding ability.The potential of these composite films in safeguarding plants from UV damage was meticulously verified.Remarkably,these PDHN NPs were first found to produce hydroxyl radicals(·OH)under UV irradiation,offering antibacterial properties that expand their potential applications.

关 键 词：MELANIN artificial allomelanin nanoparticles green synthesis UV absorption ANTIBACTERIAL 

分 类 号：TQ314.257[化学工程—高聚物工业] TB383.2[一般工业技术—材料科学与工程]