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作 者:Runze Ma Zijing Liu Bing Zhu 马润泽;刘梓菁;朱冰
机构地区:[1]National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China [2]Key Laboratory of Epigenetic Regulation and Intervention,Chinese Academy of Sciences,Beijing 100101,China [3]New Cornerstone Science Laboratory,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China
出 处:《Science Bulletin》2024年第16期2474-2475,共2页科学通报(英文版)
摘 要:Faithful DNA duplication is the fundamental event for all life forms.How to replicate the whole genome quickly and efficiently is a challenge that must be faced within every S phase of the cell cycle[1].Considering the increased size and complexity of mammalian genomes,it is plausible that the regulation of DNA replication is more intricate in mammals.Tens of thousands of replication origins have been identified throughout mammalian genomes[2].Whether replication forks originated from different origins cooperate during replication is a long-term concern in the field.
关 键 词:originated field. REPLICATION
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