Ruthenium-Catalysed Asymmetric Intramolecular Isomerization/Esterification Reaction: Direct Synthesis of Chiral Dihydrocoumarins  

作　　者：Lingzi Zhao Xuchao Wang Qing Qiang Xingwei Zhao Feipeng Liu Shenci Lu Zi-Qiang Rong 

机构地区：[1]Frontiers Science Center for Flexible Electronics(FSCFE),Shaanxi Institute of Flexible Electronics(SiFE)&Shaanxi Institute of Biomedical Materials and Engineering(SIBME),Northwestern Polytechnical University(NPU),127 West Youyi Road,Xian,Shaanxi 710072,China [2]Honors College,Northwestern Polytechnical University(NPU),127 West Youyi Road,Xi'an,Shaanxi 710072,China

出　　处：《Chinese Journal of Chemistry》2024年第16期1828-1832,共5页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(21801206);Shaanxi Fundamental Science Research Project for Chemistry&Biology(22JHQ002);the Program for Young Talents of Shaanxi Province(5113190023);the Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University(CX2023104);Natural Science Basic Research Program of Shaanxi(2024JC-ZDXM-08).

摘　　要：An asymmetric isomerization/intramolecular coupling reaction of allylic alcohols to synthesize chiral dihydrocoumarins was successfully accomplished through ruthenium catalysis.This method demonstrates a wide substrate applicability,excellent tolerance for various functional groups,and good enantioselectivities(up to 90%ee).It provides a convenient pathway to produce a diverse range ofstructurallydistinct chiral dihydrocoumarins ingoodefficiency.

关 键 词：Ruthenium catalysis Asymmetric isomerization Tandem reaction Chiral dihydrocoumarins ENANTIOSELECTIVITY 

分 类 号：O62[理学—有机化学]