Co/Fe Dual Catalysis for Sequential Hydrosilylation-Isomerization:Access to Trisubstituted(E)-Alkenyl Silanes from Terminal Alkynes  

作　　者：Zhihao Guo Guixia Liu Zheng Huang 

机构地区：[1]Chang-Kung Chuang Institute,East China Normal University,Shanghai 200062,China [2]The State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,ChineseAcademyof Sciences,Shanghai200032,China [3]School of Chemistry and Materials Science,Hangzhou Institute of Advanced Study,University of Chinese Academy of Sciences,Hangzhou,Zhejiang310024,China

出　　处：《Chinese Journal of Chemistry》2024年第16期1860-1866,共7页中国化学（英文版）

基　　金：the National Key R&D Program of China(2021YFA1500100);the National Natural Science Foundation of China(21825109,21821002,22072178,22293013);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0610000);CAS Project for Young Scientists in Basic Research(YSBR-094);Science and Technology Commission of Shanghai Municipality(23JC1404400);CAS Youth Interdisciplinary Team(JCTD-2021-11).

摘　　要：By rational modification of electronic and steric properties of pincer ligands,a Co/Fe dual catalyst system is developed for one-pot sequential Markovnikov alkyne hydrosilylation and stereoselective alkene isomerization.The protocol provides an atom-economical and efficient approach to trisubstituted(E)-alkenyl silanes from widely accessible terminal alkynes with high regio-and stereoselectivities under mild conditions.The utility of this reaction was demonstrated by gram-scale synthesis and derivatization of bioactive molecules.The radical clock and trapping experiments indicated that radical pathway might be operative in the alkene isomerization step.

关 键 词：Cobalt Dual catalysis HYDROSILYLATION Iron ISOMERIZATION Trisubstituted alkenyl silanes 

分 类 号：O62[理学—有机化学]