改性的玉米醇溶蛋白植物胶囊的制备研究  

Preparation of Plant Capsules by Compounding Modified Zein

作　　者：仝滨菲 郭嘉欣 张雪[1] 麻婷婷 于波[1] Tong Binfei;Guo Jiaxin;Zhang Xue;Ma Tingting;Yu Bo(Changchun University of Chinese Medicine,Changchun 130117,China)

机构地区：[1]长春中医药大学,吉林长春130117

出　　处：《广东化工》2024年第15期55-58,共4页Guangdong Chemical Industry

基　　金：吉林省级大学生创新创业训练计划项目(S202210199072)。

摘　　要：目的:以玉米醇溶蛋白为原料与阿拉伯胶复合,制成具有缓释作用的植物胶囊。方法:玉米醇溶蛋白与阿拉伯胶进行复合工艺研究,以紫外图谱和粘度值为指标,采用红外光谱和差示扫描量热仪进行检验;以玉米醇溶蛋白膜的水蒸气透过系数和透油性为指标,得到性能最优的配方制成植物胶囊,并进行贮存稳定性试验;以吲哚美辛为模型药物,填充于玉米醇溶蛋白植物胶囊中,磷酸盐缓冲液作为溶出介质,进行植物胶囊缓释性能的研究。结果:确定复合工艺固液比为10∶1.3,pH为6,红外光谱和差示扫描量热仪检验的结果表明形成了复合物。通过单因素实验确定最佳配方条件为:冰醋酸体积分数75%、羧甲基纤维素钠添加量0.2g、聚乙烯吡咯烷酮添加量0.4 g,将复合物0.2 g添加到上述条件中,制成植物胶囊,可使成囊率达到95%。结论:测定药物的释放度符合药典规定,说明植物胶囊具有缓释性能。Objective:Preparation of plant capsules with sustained release effect using arabic gum composite material made from corn gliadin as raw material.Methods:The compound technology of zein and gum arabic was studied,and the ultraviolet spectrum and viscosity value were used as indicators,which the infrared spectrum and differential scanning calorimeter were used for inspection;Taking the water vapor permeability coefficient and oil permeability of zein membrane as indexes,the best formula was obtained to make the plant capsule,and the storage stability test was carried out;Indomethacin was used as a model drug,filled in zein plant capsule,and phosphate buffer was used as dissolution medium to study the sustained release performance of plant capsule.Results:The solid-liquid ratio of the composite process was determined to be 10∶1.3,and the pH value was 6.The results of infrared spectroscopy and differential scanning calorimetry showed that the composite was formed.The optimum formula conditions were determined by single factor experiment as follows:75%of glacial acetic acid volume fraction,0.2 g of sodium carboxymethyl cellulose,0.4 g of polyvinylpyrrolidone,and 0.2 g of the compound was added to the above conditions to make a plant capsule,which can make the capsule rate reach 95%.Conclusion:The release determined is in accordance with the provisions of the Pharmacopoeia,indicating that the plant capsule has a sustained release performance.

关 键 词：玉米醇溶蛋白 阿拉伯胶 植物胶囊 明胶胶囊 释放度 

分 类 号：TQ[化学工程]