前沿科研成果融入药剂学实验教学——木犀草素可溶性微针的制备  

Integration of Advanced Scientific Research Results into Pharmaceutics Experimental Teaching:Preparation and in vitro Evaluation of Luteolin-loaded Dissolvable Microneedles

作　　者：吴玉梅 高杰 Wu Yumei;Gao Jie(Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学,贵州遵义563000

出　　处：《广东化工》2024年第15期200-202,共3页Guangdong Chemical Industry

基　　金：遵义医科大学教育教学改革计划项目资助项目(XJJG2022-78);遵义医科大学第三批课程思政与思政课程改革试点建设项目(XJKCSZ2023-16);遵义医科大学药学院教育教学改革计划项目(YXYJG-2023-004)。

摘　　要：为打破原有实验教学的壁垒,本文将科研前沿与药剂学实验相结合,开展实验创新改革,以提高学生的创新能力与动手能力。首先,采用模具法制备木犀草素可溶性微针,然后对其显微形态、皮肤穿刺性能、载药量及体外透皮性能进行考察。本实验可以锻炼学生制备可溶性微针的能力和创新能力,并掌握高效液相色谱仪等仪器设备的使用,认识微针的微观结构,拓宽学生的科研视野,提升科学素养。To break the barriers of the original experimental teaching,this paper combines the advanced scientific research with pharmaceutics experiment to carry out experimental innovation and reform,so as to improve students’innovative ability and practical ability.Firstly,dissolvable microneedles loaded with luteolin were prepared by mold method,and then the micromorphology,mechanical strength,skin puncture performance,drug loading and transdermal performance in vitro were investigated.This experiment can train students’ability and innovation ability to prepare dissolvable microneedles,master the use of high-performance liquid chromatography and other instruments and equipment,understand the microstructure of microneedles,broaden their scientific research horizon,and improve their scientific literacy.

关 键 词：可溶性微针 科研前沿 药剂学 实验教学 体外评价 

分 类 号：R94[医药卫生—药剂学]