对于一种治疗高脂血症的双载药控释系统的研究  

Study of a Dual-loaded Drug Controlled Release System for the Treatment of Hyperlipidemia

作　　者：付新迪 张向宇[1] 付琳 王纪宝 顾庆男 李东[1] 高晴 Fu Xindi;Zhang Xiangyu;Fu Lin;Wang Jibao;Gu Qingnan;Li Dong;Gao Qing(Jiamusi University,Jiamusi 154000,China)

机构地区：[1]佳木斯大学,黑龙江佳木斯154000

出　　处：《广东化工》2024年第16期34-38,66,共6页Guangdong Chemical Industry

基　　金：佳木斯大学大学生创新创业训练计划项目资助(202310222033)。

摘　　要：以乳化溶剂挥发法制备微球,以双药的包封率为评价指标,采用Box-behnken Design响应面法分别对SC-PP-MS的处方及工艺进行优化,并验证最优制备方案。SC-PP-MS的最优处方工艺为PEG-PLGA用量0.15 g、内水相体积170μL、外水相PVA浓度5%;磁力搅拌时间5 h、超声功率33%、超声时间5min。制得微球的粒径为(4.32±2.42)μm,PDI值为(0.216±0.076),Zeta电位(-17.23±1.87)mV。释放周期为25 d,突释较小,经拟合后SIV和CAV释放曲线均符合Ritger-Peppas释放方程,拟合结果满足0.45<n<0.89,药物在微球中释放为PEG-PLGA骨架溶蚀和药物扩散共同作用。体外释放结果显示,SIV与CAV在第25 d时,释放率分别为88.48%和91.65%,突释小释药过程平稳。Microspheres were prepared by emulsion solvent volatilization,and the encapsulation rate of two drugs,SC-PP-MS was optimized,and the optimal preparation scheme was verified.The microspheres were produced at(4.32±2.42)μm,PDI at(0.216±0.076),and Zeta potential(-17.23±1.87)mV.The release period was 25 d and the spike release was small.After fitting,the SIV and CAV release curves met the Ritger-Peppas release equation,which met 0.45<n<0.89,and the drug release in the microsphere was PEG-PLGA skeleton dissolution and drug diffusion.In vitro release results showed that at 25 d,SIV was 88.48%and 91.65%,respectively,and the process of sudden release was smooth.

关 键 词：辛伐他汀 香芹酚 PEG-PLGA 微球 降血脂 

分 类 号：R943[医药卫生—药剂学]