小儿癫痫持续状态的急诊处理及预后分析  

Emergency Management and Prognosis of Pediatric Status Epilepticus

作　　者：王海宇 WANG Haiyu(Department of Pediatric Emergency,Anhui Children's Hospital,Children's Hospital of Fudan University,Hefei 230000,China)

机构地区：[1]复旦大学附属儿科医院安徽医院(安徽省儿童医院)儿童急诊科,安徽合肥230000

出　　处：《中华灾害救援医学》2024年第7期797-799,共3页Chinese Journal of Disaster Medicine

摘　　要：目的探索不同急症处理方案在小儿癫痫持续状态(Status Epilepticus,SE)中的应用效果。方法选取2021年5月至2024年3月安徽省儿童医院收治的260例癫痫持续状态患儿,根据急诊方案分为观察组(咪达唑仑+地西泮+苯巴比妥)和对照组(地西泮+苯巴比妥),每组各130例。比较两组患儿临床疗效、治疗前后癫痫情况、治疗时间、不良反应。结果观察组的临床有效率为91.54%,高于对照组的72.31%(P<0.001)。治疗后,两组STESS评分均较治疗前显著降低(P<0.001),观察组治疗后STESS评分显著低于对照组(P<0.001)。观察组治疗所需时长短于对照组(P<0.001)。观察组的不良反应的发生率为14.62%,低于对照组的31.54%(P=0.001)。结论地西泮、苯巴比妥联合咪达唑仑治疗小儿癫痫持续状态临床疗效显著,可明显改善癫痫持续状态,且不良反应少,患者预后良好。Objective To explore the application effects of different emergency treatment regimens in pediatric status epilepticus(SE).Methods 260 children with status epilepticus admitted to Anhui Children's Hospital from May 2021 to March 2024 were selected and divided into the observation group(midazolam+diazepam+phenobarbital)and the control group(diazepam+phenobarbital)according to the emergency plan,with 130 cases in each group.Clinical efficacy,epilepsy status before and after treatment,treatment duration,and adverse reactions were compared between the two groups.Results The clinical effective rate in the observation group was 91.54%,which was significantly higher than that(72.31%)in the control group(P<0.001).After treatment,STESS scores in both groups were significantly lower than that before treatment(P<0.001),and the post-treatment STESS score in the observation group was significantly lower than that in the control group(P<0.001).The treatment duration in the observation group was shorter than that in the control group(P<0.001).The incidence of adverse reactions in the observation group was 14.62%,which was lower than that(31.54%)in the control group(P=0.001).Conclusion The combination of diazepam,phenobarbital,and midazolam in the treatment of pediatric status epilepticus has significant clinical efficacy,can significantly improve the epileptic condition,has fewer adverse reactions,and leads to better patient prognosis.

关 键 词：癫痫持续状态 儿童 急诊处理 

分 类 号：R742.1[医药卫生—神经病学与精神病学]