EGFR、Ki-67表达与原发性肝癌根治性手术预后的相关性  

The Correlation between EGFR and Ki-67 Expression and the Prognosis of Radical Surgery for Primary Liver Cancer

作　　者：王晓建[1] WANG Xiaojian(Nanyang First People's Hospital,Nanyang Henan 473000)

机构地区：[1]南阳市第一人民医院,河南南阳473000

出　　处：《医学临床研究》2024年第8期1160-1163,共4页Journal of Clinical Research

摘　　要：【目的】探讨癌组织中表皮生长因子受体(EGFR)、Ki-67表达与原发性肝癌(HCC)根治性手术后预后的关系。【方法】选取2015年6月至2018年6月本院收治的103例HCC患者,患者均行HCC根治性手术及术后预防性导管动脉化疗栓塞,术后随访3年。检测并比较癌组织、癌旁组织中EGFR、Ki-67表达情况,分析癌组织中EGFR、Ki-67表达与病理因素关系,分析影响HCC根治术患者预后的因素及癌组织中EGFR、Ki-67表达与HCC术后预后的关系。【结果】癌组织中EGFR、Ki-67阳性表达率均高于癌旁组织(P<0.05)。有微血管癌栓、肿瘤包膜不完整、临床Ⅲ期及低分化患者癌组织EGFR、Ki-67阳性表达率分别高于无微血管癌栓、肿瘤包膜完整、临床Ⅰ~Ⅱ期、中高分化患者(P<0.05)。Cox回归分析显示,微血管癌栓、肿瘤包膜、临床分期、分化程度情况及EGFR表达、Ki-67表达是影响HCC患者无病生存率的相关因素(P<0.05);肿瘤包膜、临床分期、分化程度情况及EGFR表达、Ki-67表达是影响总生存率的相关因素(P<0.05)。EGFR、Ki-67阴性表达患者的无病生存率、总生存率均优于阳性表达患者,差异有统计学意义(P<0.05)。【结论】HCC患者癌组织中EGFR、Ki-67异常高表达,EGFR、Ki-67表达与HCC术后患者病理、预后有关,阳性表达者预后不良风险高。【Objective】To investigate the relationship between the expression of epidermal growth factor receptor(EGFR)and Ki-67 in cancer tissues and the postoperative prognosis of primary liver cancer(HCC).【Methods】A total of 103 HCC patients admitted to the hospital from June 2015 to June 2018 were selected.All patients underwent HCC radical surgery and postoperative prophylactic transcatheter arterial chemoembolization,and were followed up for 3 years after surgery.We detected and compared the expression of EGFR and Ki-67 in cancer tissues and adjacent tissues,analyzed the relationship between EGFR and Ki-67 expression in cancer tissues and pathological factors,analyzed the factors affecting the prognosis of HCC radical surgery,and analyzed the relationship between EGFR and Ki-67 expression in cancer tissues and postoperative prognosis of HCC.【Results】The positive expression rates of EGFR and Ki-67 in cancer tissues were higher than those in adjacent tissues(P<0.05).The positive expression rates of EGFR and Ki-67 in cancer tissues of patients with microvascular tumor thrombus,incomplete tumor capsule,clinical stageⅢ,and low differentiation were higher than those of patients without microvascular tumor thrombus,intact tumor capsule,clinical stageⅠ-Ⅱ,and moderately to well differentiated patients(P<0.05).Cox regression analysis showed that microvascular tumor thrombus,tumor capsule,clinical stage,differentiation degree,EGFR expression,Ki-67 expression were related factors affecting disease-free survival rate(P<0.05);Tumor capsule,clinical stage,differentiation degree,EGFR expression,and Ki-67 expression are related factors affecting overall survival rate(P<0.05).The disease-free survival rate and overall survival rate of EGFR and Ki-67 negative expression patients were better than those of positive expression patients,and the differences were statistically significant(P<0.05).【Conclusion】EGFR and Ki-67 are abnormally overexpressed in cancer tissues of HCC patients.EGFR and Ki-67 expression are associa

关 键 词：肝肿瘤/外科学 KI-67抗原 基因 erbB-1 预后 

分 类 号：R735.7[医药卫生—肿瘤]