TRIM28蛋白结构和功能及其在肿瘤中的研究进展  

The structure and function of TRIM28 protein and its research progress in tumor

作　　者：侯雪阳 宋丹丹 徐晓珍 肖帅 周策凡 唐景峰 HOU Xueyang;SONG Dandan;XU Xiaozhen;XIAO Shuai;ZHOU Cefan;TANG Jingfeng(Department of Biomedicine/Institute of Biomedicine,College of Bioengineering and Food Science,Hubei University of Technology,Hubei Wuhan 430068,China;National"111"Research Center for Cell Regulation and Molecular Drugs,Hubei University of Technology,Hubei Wuhan 430068,China)

机构地区：[1]湖北工业大学生物工程与食品学院生物医药系/生物医药研究院,湖北武汉430068 [2]湖北工业大学国家细胞调控与分子药物“111”引智基地,湖北武汉430068

出　　处：《现代肿瘤医学》2024年第18期3589-3596,共8页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:82273970);湖北工业大学人才引进项目(编号:XJ2022003901)。

摘　　要：三基序蛋白28(tripartite motif 28,TRIM28)是一种E3泛素连接酶,属于TRIM(tripartite motif-containing,TRIM)家族,具有典型的RBCC(RING、B-box、Coiled-coil)结构域和多变的羧基端结构域。TRIM28在细胞核和细胞质中均有分布,除了具有E3泛素连接酶活性,还具有SUMO E3泛素连接酶活性,并且可作为转录因子调节靶基因的转录。TRIM28在细胞的增殖与分化过程中发挥重要的作用,同时也参与了癌症相关信号通路,从而促进非小细胞肺癌、乳腺癌和胃癌等多种癌细胞的增殖、侵袭和迁移,抑制细胞凋亡的发生。该文就TRIM28的蛋白结构、生物学功能、信号通路及其在肿瘤发生发展中的作用研究进行综述。Tripartite motif 28(TRIM28)is an E3 ubiquitin ligase belonging to the tripartite motif-containing(TRIM)family.It has a typical RBCC(RING,B-box,Coiled-coil)domain and a variable C-terminal domain.TRIM28 is distributed in the nucleus and cytoplasm.In addition to E3 ubiquitin ligase activity,it also has SUMO E3 ubiquitin ligase activity and can be used as a transcription factor to regulate the transcription of target genes.TRIM28 plays an important role in cell proliferation and differentiation,and is also involved in cancer-related signaling pathways,thereby promoting the proliferation,invasion,and migration of many common cancer cells such as non-small cell lung cancer,breast cancer,and gastric cancer,and inhibiting the occurrence of apoptosis.In this paper,the protein structure,biological function,signaling pathway of TRIM28,and its role in tumorigenesis and development are reviewed.

关 键 词：TRIM28 E3泛素连接酶 功能 肿瘤 

分 类 号：R730.231[医药卫生—肿瘤]